Diagnosis Method for Lupus
Inactive Publication Date: 2017-03-16
INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM) +2
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Benefits of technology
The invention provides methods for diagnosing lupus by analyzing proteins in a biological sample, such as blood or urine. These methods can be performed using a protein extract prepared from the sample or commercially available kits. The results obtained from these methods can be compared and combined with other tests and procedures to provide a more refine diagnosis of lupus. The technical effect of this invention is to provide a reliable and accurate method for diagnosis of lupus.
Problems solved by technology
As in other autoimmune diseases, the body's immune system attacks the body's own tissues and organs, leading to inflammation.
It takes on average 4 years to obtain a correct diagnosis for lupus, in part due to the range and complexity of symptoms and the necessity to discount other possible causes.
Some of these criteria are very specific for lupus but have poor sensitivity, but none of these tests provides a definitive diagnosis and so the results of multiple differing tests must be integrated to enable a clinical judgement by an expert.
Diagnosis can therefore be challenging.
By opposition, patients with SSc who do not have ATA or ACA are difficult to diagnose or classify.
Method used
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Material & Methods
[0109]Participants' Characteristics
[0110]For ProtoArray analysis, plasma samples from 20 patients with SSc including 8 patients negative for ATA and ACA (Abneg), 6 positive for ATA and 6 positive for ACA were recruited from 5 French hospitals. Patients with SSc were compared to 18 controls, including 8 healthy individuals with no history of autoimmune diseases (AID) recruited at the Centre d'Examen de Santé de l'Assurance Maladie (CESAM), Marseille, France and 10 patients with other AID including Rheumatoid Arthritis (RA), Systemic Erythematous Lupus (SLE) and Localized Scleroderma (LocSc) recruited in the Rheumatology Unit of St Marguerite Hospital in Marseille. The patients' autoantibody profile (ATA, ACA, Abneg) and patients' disease subtype (Lc-SSc, Dc-SSc) was obtained by reviewing medical records. It is to note that Abneg patients are negative for ATA and ACA but could be positive for other autoantibodies (anti-RNA polymerase III, anti-U3RNP . . . ) but this ...
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The present invention relates to an in vitro method for diagnosing lupus in a subject, said method comprising the step of detecting in a biological sample obtained from the subject the autoantibody recognizing the protein biomarker THEX1. More, the invention relates to kits and array useful for carrying out diagnosis methods according to the present invention.
Description
FIELD OF THE INVENTION[0001]The present invention relates to an in vitro method for diagnosing lupus in a subject, said method comprising the step of detecting in a biological sample obtained from the subject the autoantibody recognizing the protein biomarker THEX1.[0002]More, the invention relates to kits and array useful for carrying out diagnosis methods according to the present invention.BACKGROUND OF THE INVENTION[0003]Systemic lupus erythematosus (SLE) or lupus is a chronic autoimmune disease that can affect the joints and almost every major organ in the body, including heart, kidneys, skin, lungs, blood vessels, liver, and the nervous system. As in other autoimmune diseases, the body's immune system attacks the body's own tissues and organs, leading to inflammation. A person's risk to develop lupus appears to be determined mainly by genetic factors, but environmental factors, such as infection or stress may trigger the onset of the disease. The course of lupus varies, and is ...
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Login to View More IPC IPC(8): G01N33/564
CPCG01N2800/104G01N33/564
Inventor LAMBERT, NATHALIEARNOUX, FANNYAZZOUZ, DOUA
Owner INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM)