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Compositions containing combinations of sunscreen active agents

a technology of sunscreen active agents and compositions, applied in the field of compositions containing combinations of sunscreen active agents, can solve the problems of difficult increase of spf of compositions containing sunscreen active agents, and achieve the effect of increasing the sun protection factor (spf) properties

Active Publication Date: 2017-07-06
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to compositions for keratinous materials (hair or skin) that provide increased sun protection. The compositions contain specific ratios of octocrylene, octinoxate, octisalate, and homosalate. Additionally, the compositions may also contain metal oxides, such as zinc oxide or titanium dioxide. The use of these ratios and metal oxides results in a synergistic effect that increases the sun protection factor (SPF) of the compositions. The technical effect of the invention is to provide more effective sun protection with the use of specific ratios of ingredients.

Problems solved by technology

However, given the finite amount of approved sunscreen active agents worldwide, increasing SPF of compositions containing sunscreen active agents can be difficult.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Inventive Compositions of UV Filters

[0188]Organic sunscreen active agents were combined with a film former, Dermacryl 79, and dissolved in a solvent, ethanol.

Octocrylene1-6wt %OMC2-7.5wt %Octisalate2-5wt %Homosalate1-8wt %Total UV Filters10wt %Film former2.5wt %Ethanolq.s.

[0189]Sample mixtures of sunscreens were applied to the smoothened side of a PMMA (polymethyl methacrylate) plate using a draw down bar to control thickness and homogeneity of the film. In vitro SPF was measured using a Labsphere 2000. Each sample was measured at 6 locations per plate on 3 separate plates so an average in vitro SPF value may be obtained for each sunscreen mixture.

Inventive and Comparative Sunscreen Mixtures.*InventiveMeanWt % ratioWt % ratioWt % ratio Wt % ratioMixture?SPFOctocrylene:HoniosalateOctinoxate:OctisalateOctocrylene:OctinoxateOctocrylene:OctisalateY53.283.00**1.00**2.25**2.25**Y50.194.50**0.80**2.25**1.80**Y43.263.50**1.20**1.17**1.40**Y43.003.50**1.25**1.40**1.75**Y42.603.50**1.00**1.75...

example 2

Preparation of Inventive Compositions Comprising Sunscreens and Metal Oxides

[0191]Octocrylene, octinoxate, octisalate and homosalate, and other organic sunscreen active agents (if present), can be mixed into an oil phase of a formulation, and then combined with metal oxides.

[0192]If the final formulation is an emulsion, the emulsion can be formed first with organic sunscreen active agents in the oil phase to create a “white base”, at which time the metal oxides can added to the white base. In this scenario, the metal oxides can be added as a separate jet-milled preparation with another powder or filler, added to the white base without any additional ingredients, or added to the white base as a separate multiple-phase or single-phase paste, gel, cream, or suspension.

[0193]Alternatively, the metal oxides can be combined with the organic sunscreen active agents prior to forming an emulsion, or during the preparation of the formula, as a single phase preparation.

example 3

Inventive Composition with Metal Oxides

[0194]

PhaseIngredientwt %ASolventq.s.Water-in-oil emulsifiers4.50%Homosalate1.50%Ethylhexyl salicylate2.00%Octocrylene4.50%Ethylhexyl Methoxycinnamate2.00%Disteardimonium Hectorite0.40%Film Former5.00%B1Water35.52% Capryly Glycol0.55%Glycerin5.00%Dipropylene Glycol2.00%Preservatives0.50%Polyacrylate thickener3.00%CFillers4.94%Metal Oxide pigments9.00%

[0195]The inventive composition containing 10 wt % total organic sunscreens was applied to the roughened side of a PMMA plate with a finger at 2mg / cm2. The in vitro SPF was measured at 5 locations per plate on 3 separate plates. Average in vitro SPF was 20.07.

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Abstract

Compositions containing octocrylene, octinoxate, octisalate, homosalate and having improved sun protection factor (SPF) properties, as well as methods of improving sun protection factor (SPF) properties of compositions, are provided.

Description

FIELD OF THE INVENTION[0001]The present invention relates to compositions containing combinations of sunscreen active agents and having improved sun protection factor (SPF) properties.BACKGROUND OF THE INVENTION[0002]Compositions containing sunscreen active agents are highly popular. Sunscreen active agents in such compositions protect keratinous material such as hair and skin from the harm caused by UV radiation, including harm from both UVA and UVB rays. A standard measure for determining the amount of protection a composition containing sunscreen active agent provides against UV radiation, particularly against UVB rays, is sun protection factor (SPF). However, given the finite amount of approved sunscreen active agents worldwide, increasing SPF of compositions containing sunscreen active agents can be difficult.[0003]U.S. patent application 2013 / 0129649 refers to a mixture of sunscreens which cannot be used in conjunction with oxides such as titanium dioxide and zinc oxide (namel...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/40A61K8/19A61Q17/04A61K8/37
CPCA61K8/40A61K8/37A61K2800/5922A61Q17/04A61K8/19
Inventor BODNAR, BRIAN SCOTTAWOFESOBI, OMOTAYOSHAH, ANIL
Owner LOREAL SA
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