Cutting Apparatus for Bioprocessing Bone

Inactive Publication Date: 2019-11-14
OSSIUM HEALTH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0009]To enable cryopreservation of whole bone and facilitate subsequent processing of the bone, an apparatus is provided which can be used to process the bone and recover bone marrow to a cellular suspension prior to cryopreservation, or to enable the cryopreservation of whole bone to be subsequently processed. The apparatus allows either a fres

Problems solved by technology

This step is repeated many times, typically in both pelvic bones, and can often result in contamination of the aspirate.
Immediate cryopreservation of tissues is more practical than direct pr

Method used

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  • Cutting Apparatus for Bioprocessing Bone
  • Cutting Apparatus for Bioprocessing Bone
  • Cutting Apparatus for Bioprocessing Bone

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Embodiment Construction

[0039]For the purposes of promoting an understanding of the principles of the disclosure, reference will now be made to the embodiments illustrated in the drawings and described in the following written specification. It is understood that no limitation to the scope of the disclosure is thereby intended. It is further understood that the present disclosure includes any alterations and modifications to the illustrated embodiments and includes further applications of the principles disclosed herein as would normally occur to one skilled in the art to which this disclosure pertains

[0040]An apparatus 10 is provided, as shown in FIG. 1, for cutting a bone segment recovered from organ and tissue donors for subsequent processing. The apparatus includes a frame formed by a base plate 11 supporting four vertical columns 12. The frame also includes a top plate 14 is mounted on the four vertical columns and an intermediate plate 16 is mounted to the columns at a position between the base plate...

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Abstract

A bone cutting assembly includes a manually actuated upper cutting element that carries a plurality of cutting blades configured to cut through frozen bone segments. A lower cutting element supports a bone segment to be cut and can include cutting blades aligned with the cutting blades of the upper cutting assembly. A pivoting linkage or a rack and pinion arrangement can be provided between the upper cutting element and a manually operated handle to provide sufficient mechanical advantage or leverage to allow an operator to manually cut through the bone.

Description

PRIORITY CLAIM[0001]This application is a utility filing from and claims priority to co-pending application No. 62 / 670,283, filed on May 11, 2018, the entire disclosure of which is incorporated herein by reference.BACKGROUND[0002]The present disclosure concerns an apparatus useful for recovering live bone marrow.[0003]Bone marrow for clinical purposes is harvested from HLA matched siblings or optimally matched unrelated donors (MUD). Other graft sources are mismatched haploidentical related or unrelated donors and umbilical cord blood (CB). When transplanted into patients with certain diseases, the hematopoietic stern cells (HSCs) in the donor bone marrow engraft in the patient and reconstitute immune and hematopoietic systems.[0004]Bone marrow is also a source for mesenchymal stromal / stem cells (MSCs) which are self-renewing, multipotent progenitor cells with multilineage potential to differentiate into cell types of mesodermal origin, such as adipocytes, osteocytes, and chondrocyt...

Claims

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Application Information

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IPC IPC(8): A01N1/02C12N5/077
CPCA01N1/0236C12N2509/10C12N5/0669A61F2/4644A61B17/16A61B17/1611
Inventor WOODS, ERIK J.JOHNSTONE, BRIANINGALLS, JOSEPH
Owner OSSIUM HEALTH INC
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