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Skin product sweat testing devices and methods

a technology for skin products and testing devices, applied in the field of skin product sweat testing devices and methods, can solve the problems of artificial skins developed, difficult control, and high cost of approaches, and achieve the effects of improving the quality of skins, and improving the safety of skins

Active Publication Date: 2020-08-13
UNIVERSITY OF CINCINNATI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is about devices and methods for testing sweat properties from skin using smart sweat stimulation devices. These devices have multiple sweat rates, durations, and control tests that can be co-located on a person. The device includes a plurality of different sweat stimulation sites that may be used to measure the sweat property or deliver the sweat stimulant to the skin using an electrode. The sweat stimulant used may be acetylcholine, carbachol, methacholine, bethanechol, muscarine, pilocarpine, oxotremorine, or combinations thereof. The methods of testing materials or components may involve sweat stimulation or measuring sweat production. The invention allows for more accurate and precise testing of sweat properties.

Problems solved by technology

This is challenging, because inducing sweating in these product tests is typically a global body event and is difficult to control (e.g., using a hot-room, exercise, stress, etc.).
This approach is also costly, cumbersome, and can have great variation across each subject or within each subject who participates.
Artificial skins have been developed but have difficulty mimicking the full nature of live human skin and its environment.

Method used

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  • Skin product sweat testing devices and methods

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018]A skin adhesive product is to be tested for its adhesive strength and longevity in the presence of sweat. A device, such as device 100, includes components 172, 174, 176, which all include the product to be tested. The device is placed on skin to test each of the products 172, 174, 176 against different durations of sweating. A prolonged response of sweating is generated where the product 172 experiences a sweat generation rate of greater than 0.5 nL / min / gland for 2 hours and the product 174 experiences a sweat generation rate of greater than 0.5 nL / min / gland for 6 hours. The product 176 is used as a control and experiences no sweating (i.e., the sweat glands under the product 176 undergo no stimulation). To produce the varied prolonged responses for the products 172, 174, the dose of sweat stimulant such as carbachol delivered to the skin may be controlled (e.g., charge / second and / or duration).

[0019]When sweat stimulation is applied using the configuration of the device 100 o...

example 2

[0022]A skin antiperspirant product is to be tested for its efficacy in stopping or slowing perspiration over time. Sweat stimulants that generate sweating responses of different durations may be applied to distinct areas of the skin to test the antiperspirant product over the different durations. With reference to FIG. 1A, the sweat stimulant reservoirs 142, 144, 146 could contain acetylcholine, pilocarpine, and carbachol, respectively. A short (e.g., 1 minute) but equal dose (0.5 mA / cm2) of the acetylcholine, pilocarpine, and carbachol could be delivered by the electrodes 152, 154, 156, respectively.

[0023]After stimulation was applied with FIG. 1A, the device 100 could be quickly removed and antiperspirant product applied within 1 minute to 2 more minutes. Within 5 minutes, generated sweat would appear. Due to the different stimulants used, the areas of the skin adjacent to the reservoirs 142, 144, 146 would generate stimulated sweating for different durations. The sweating respon...

example 3

[0024]Experiments are conducted similar to that of the previous example, but no skin product is tested, rather the natural state or health or disease of skin is tested. For example, eczema, a rash, skin hydration, microflora, or other factors on skin and skin health could be tested as a function of sweat generation rate. Measures could include photographs, spectrometry, analytical chemistry, or other known methods for analyzing the status of skin.

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Abstract

Described are methods and devices (100) for measuring a sweat property of skin (12) in response to at least one test material or component (172, 174, 176, 178). Embodiments of the device include a plurality of different sweat stimulation sites. The Sweat stimulation sites may include one or more sweat stimulant reservoirs (142, 144, 146, 148) configured to deliver a sweat stimulant to the surface of the skin (12). Embodiments may also include at least one electrode (150, 152, 154, 156, 158) for measuring a sweat property or to iontophoretically deliver the sweat stimulant from the reservoir (142, 144, 146, 148). In embodiments, the sweat stimulant is selected from acetylcholine, carbachol, methacholine, bethanechol, muscarine, pilocarpine, oxotremorine, and combinations thereof.

Description

BACKGROUND[0001]Skin product testing often involves the influence of sweat on the product performance, such as adhesives, textiles, cosmetics, therapeutics, or any other type of testing of a product or even a skin condition. This is challenging, because inducing sweating in these product tests is typically a global body event and is difficult to control (e.g., using a hot-room, exercise, stress, etc.). This approach is also costly, cumbersome, and can have great variation across each subject or within each subject who participates. Artificial skins have been developed but have difficulty mimicking the full nature of live human skin and its environment.SUMMARY OF THE INVENTION[0002]Embodiments of the disclosed invention provide devices and methods for digitized skin product sweat testing. Unlike conventional methods, using smart sweat stimulation devices and methods, multiple sweat rates, sweat durations, and control tests can be co-located on a subject.[0003]Described are devices fo...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B5/145A61B5/053A61N1/04A61B5/00A61N1/30
CPCA61N1/0496A61B5/0531A61B5/14521A61N1/30A61B5/6832A61N1/0448A61B5/4266A61B5/6801A61N1/0476A61N1/0484A61N1/325
Inventor HEIKENFELD, JASON C.
Owner UNIVERSITY OF CINCINNATI