Extraction of pharmaceutically active components from plant materials

a technology of plant materials and active components, which is applied in the direction of solvent extraction, plant/algae/fungi/lichens ingredients, separation processes, etc., to achieve the effect of increasing the selectivity of the extraction process and improving the stability of the final bds

Inactive Publication Date: 2020-10-01
GW PHARMA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0057]A step of treatment with activated charcoal may be included between step iv) and step v), resulting in improved stability of the final BDS.
[0058]The applicant has further determined that the addi

Problems solved by technology

Furthermore, CO2 extraction is a conservative method of preparat

Method used

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  • Extraction of pharmaceutically active components from plant materials
  • Extraction of pharmaceutically active components from plant materials
  • Extraction of pharmaceutically active components from plant materials

Examples

Experimental program
Comparison scheme
Effect test

example 2-investigation

of the Stabilisation of Botanical Drug Substance (BDS) by Partial Purification Using Activated Charcoal

[0191]Results from stability studies on THC formulations indicate that THC in the form of BDS is unstable even at storage temperatures as low as 5° C. This contrasts with the behaviour of the purified THC (Dronabinol USP) in Marinol soft gel capsules, for which a shelf life of 2 years at cool ambient temperature is accepted. It should also be noted that the shelf life of THC standard solutions in methanol supplied by Sigma-Aldrich is claimed to be 4 years when stored refrigerated and protected from light.

[0192]This apparent discrepancy between the stability of BDS (THC) and purified THC prompted speculation that some component of BDS was destabilising the principal cannabinoid.

[0193]A solution to this problem would be to purify the BDS (THC) to yield high purity, preferably crystalline cannabinoid. However, the additional processing costs incurred on transforming BDS to pure cannab...

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Abstract

The invention relates to the extraction of pharmaceutically active components from plant materials, and more particularly to the preparation of a botanical drug substance (BDS) for incorporation in to a medicament. It also relates to a BDS of given purity, for use in pharmaceutical formulations. In particular it relates to BDS comprising cannabinoids obtained by extraction from cannabis.

Description

RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 15 / 467,387, filed Mar. 23, 2017, which is a continuation of U.S. patent application Ser. No. 12 / 049,588, filed Mar. 17, 2008, which is a divisional of U.S. patent application Ser. No. 10 / 218,972, filed Aug. 14, 2002, now U.S. Pat. No. 7,344,736, the entire contents of each of which are incorporated herein by reference in their entireties.FIELD OF THE INVENTION[0002]The present invention relates to the extraction of pharmaceutically active components from plant materials, and more particularly to the preparation of a botanical drug substance (BDS) for incorporation in to a medicament. It also relates to a BDS of given purity, for use in pharmaceutical formulations. In particular it relates to BDS comprising cannabinoids obtained by extraction from cannabis. BACKGROUND OF THE INVENTION[0003]In PCT / GB02 / 00620 the applicant discloses a method of preparing a herbal drug extract (botanical dru...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K31/352B01D11/02
CPCY02A50/30A61K36/185A61K31/352B01D11/0203
Inventor WHITTLE, BRIAN ANTHONYHILL, COLIN A.FLOCKHART, IAN R.DOWNS, DAVID VICTORGIBSON, PETERWHEATLEY, GARY WILLIAM
Owner GW PHARMA LTD
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