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Method and kit for the diagnosis of colorectal cancer

a colorectal cancer and kit technology, applied in the direction of biochemistry equipment and processes, instruments, material analysis, etc., to achieve the effect of high specificity and high sensitivity

Inactive Publication Date: 2021-07-15
ALMA MATER STUDIORUM UNIV DI BOLOGNA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a better way to diagnose a certain medical condition. The method and kit have very strong ability to detect the condition with high sensitivity and specificity.

Problems solved by technology

In the field of CRC diagnosis, for instance, the Fecal Occult Blood Test (FOBT), though highly specific (being in fact able to identify even very small blood traces present in the feces), is not very sensitive, as it is unable to discriminate the cases in which bleeding occurs for reasons independent of a tumor presence, so much that only one third of FOBT-positive cases are found to be diseased in a subsequent colonoscopy inspection.

Method used

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  • Method and kit for the diagnosis of colorectal cancer
  • Method and kit for the diagnosis of colorectal cancer

Examples

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examples

[0093]The following examples aim at illustrating the invention without absolutely being limitative thereof.

[0094]The studies which led to the present invention were approved by the Ethics Committee is of the “Sant'Orsola-Malpighi” Hospital of Bologna, Italy, and meet the requirements of the Helsinki Declaration of Ethical Principles for medical research involving human subjects.

[0095]All subjects involved signed an informed consent form before the start of the studies.

[0096]Peripheral blood samples were obtained from 67 healthy donors and 56 non-correlated patients with histological analysis confirming CRC at any stage, prior to surgical therapy and without addition of chemical or radiological treatments to the surgical therapy.

[0097]To reduce the risk of sample contamination from needle-carried epithelial cells, the first ml of blood was discarded.

[0098]RNA Extraction

[0099]Whole blood, put in a tube containing EDTA, was treated for lysis within one hour from collection, by adding t...

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Abstract

The present invention relates to a method for the diagnosis of colorectal cancer from a sample of blood or blood fractions, and to a kit for said diagnosis.

Description

[0001]This application is a divisional application of U.S. application Ser. No. 15 / 576,225, filed Nov. 21, 2017, which is the U.S. national phase of International Application No. PCT / IB2016 / 052999, filed May 23, 2016, which designated the U.S. and claims priority to Application No. IT 102015000016638, filed May 21, 2015; the entire contents of each of which are hereby incorporated by reference.DESCRIPTION[0002]The present invention relates to a method for the diagnosis of colorectal cancer from a sample of blood or blood fractions and a kit for said diagnosis.PRIOR ART[0003]Colorectal cancer (CRC) is the third most common cancer worldwide, with almost 1.4 million new cases diagnosed in 2012. A significant survival rate is obtained if the primary tumor is detected at an early stage.[0004]In most CRC cases a multi-stage process develops, starting with benign precancerous adenomas that develop into aggressive metastatic carcinoma. This makes early diagnosis fundamental in order to bene...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/158G01N2333/705G01N2333/78G01N2333/70503G01N2333/4724
Inventor SOLMI, ROSSELLAMATTEI, GABRIELLAUGOLINI, GIAMPAOLORODIA, MARIALAURIOLA, MATTIAMONTRONI, ISACCO
Owner ALMA MATER STUDIORUM UNIV DI BOLOGNA
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