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Adipocyte Insulin adpinsl with Insulin A and B chains and an effective method of treating type 2 diabetes in a subject using adipocyte insulin

a technology of adipocyte insulin and adpinsl, which is applied in the field of adipocyte insulin adpinsl, can solve the problems of inability to find an alternative insulin besides pancreatic p-cells, and achieve the effect of improving the quality of li

Inactive Publication Date: 2006-10-31
COUNCIL OF SCI & IND RES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is about a new type of insulin called adipocyte insulin. This insulin is made from adipocytes, which are cells found in the body. The invention also includes a method for using this new insulin to treat type 2 diabetes. The method involves giving the insulin to diabetics through a needle in the abdomen. The invention also includes a process for isolating the insulin from the adipocytes of carp. The invention also includes a method for identifying and producing the insulin from the adipocytes of a catla catla fish. Overall, the invention provides a new way to treat diabetes and a new source of insulin for this purpose.

Problems solved by technology

Search for an alternative insulin besides pancreatic P-cell has not yet been successful.

Method used

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  • Adipocyte Insulin adpinsl with Insulin A and B chains and an effective method of treating type 2 diabetes in a subject using adipocyte insulin
  • Adipocyte Insulin adpinsl with Insulin A and B chains and an effective method of treating type 2 diabetes in a subject using adipocyte insulin
  • Adipocyte Insulin adpinsl with Insulin A and B chains and an effective method of treating type 2 diabetes in a subject using adipocyte insulin

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Embodiment Construction

[0009]The present invention relates to an adipocyte Insulin adpInsl with Insulin A and B chains of SEQ ID Nos. 1 and 2, a effective method of treating type 2 diabetes in a subject using adipocyte insulin, said method comprising steps of administering the insulin to a diabetic intraperitoneally, an Insulin gene of SEQ ID No. 3, a process of isolating protein Insulin from the adipocytes of the Carp, said method comprising steps of reverse transcripting RNA of adipocytes to obtain cDNA, using oligonucleotide primers of SEQ ID Nos. 5 and 6 to identify AdpInsl gene from cDNA, and deducing amino acid sequence from cDNA to obtain protein Insulin, and an adipocyte of Catla Catla useful for producing the said Insulin.

[0010]In an embodiment of the present invention, wherein an adipocyte Insulin adpInsl with Insulin A and B chains of SEQ ID Nos. 1 and 2.

[0011]In yet another embodiment of the present invention, wherein the SEQ ID no. 1 is of length 21 amino acids.

[0012]In still another embodime...

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Abstract

The present invention relates to an adipocyte Insulin adpInsl with Insulin A and B chains of SEQ ID Nos. 1 and 2, a effective method of treating type 2 diabetes in a subject using adipocyte insulin, said method comprising steps of administering the insulin to a diabetic intraperitoneally, an Insulin gene of SEQ ID No. 3, a process of isolating protein Insulin from the adipocytes of the Carp, said method comprising steps of reverse transcripting RNA of adipocytes to obtain cDNA, using oligonucleotide primers of SEQ ID Nos. 5 and 6 to identify AdpInsl gene from cDNA, and deducing amino acid sequence from cDNA to obtain protein Insulin, and an adipocyte of Catla Catla useful for producing the said Insulin.

Description

FIELD OF THE PRESENT INVENTION[0001]The present invention relates to an adipocyte Insulin adpInsl with Insulin A and B chains of SEQ ID Nos. 1 and 2, a effective method of treating type 2 diabetes in a subject using adipocyte insulin, said method comprising steps of administering the insulin to a diabetic intraperitoneally, an Insulin gene of SEQ ID No. 3, a process of isolating protein Insulin from the adipocytes of the Carp, said method comprising steps of reverse transcripting RNA of adipocytes to obtain cDNA, using oligonucleotide primers of SEQ ID Nos. 5 and 6 to identify AdpInsl gene from cDNA, and deducing amino acid sequence from cDNA to obtain protein Insulin, and an adipocyte of Catla Catla useful for producing the said Insulin.BACKGROUND AND PRIOR ART REFERENCE OF THE PRESENT INVENTION[0002]Insulin gene expression and secretion of insulin protein in all animals including human being is still known to be pancreatic p-cell specific. Search for an alternative insulin besides...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K38/28C07H21/04C07K14/62A61K38/00C07K14/46C12N15/17
CPCC07K14/461A61K38/00
Inventor BHATTACHARYA, SAMIRROY, SIB SANKARDASGUPTA, SUBRATAMUKHERJEE, MOHUA
Owner COUNCIL OF SCI & IND RES
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