A device for coupling to a fluid connector of an IV administration set to resistcontamination of the fluid connector and IV administration set and permit prim- ing of the IV administration set. The device including a cover body having a cavity for receiving the fluid connector, a priming passage for priming fluid from the IV admin- istration set through the fluid connector, and a coupling tab extending from the cover body, the coupling tab permitting the cover body to be coupled to a length of an IV line or other portion of the IV administration set to resistcontamination and permit priming of the IV administration set.