The invention relates to the field of preparation of natural products, and particularly provides self-assembled granules for improving the auxiliary
gastric mucosa protection effect of
piperine and a preparation method of the self-assembled granules. The method comprises the following steps: dissolving
piperine and
mallotus oblongifolius
polyphenol, mixing, adjusting the pH value, heating, concentrating, purifying and
drying. According to the
piperine self-
assembly nano-particles and the preparation method thereof, the problems that in the self-
assembly process of natural products, the structure is complex, and subtle equilibrium relation exists among compounds are solved, the piperine self-
assembly nano-particles are successfully prepared, and the piperine auxiliary
gastric mucosa protection capacity can be remarkably improved only by 20 mg / kg and b.w. In addition, the piperine and the
mallotus oblongifolius
polyphenol are separated and recovered based on the natural eutectic
solvent aqueous two-phase
system, the method has the advantages of being large in extraction amount, easy to operate, mild in preparation condition, high in selectivity,
environmentally friendly and efficient, and the problems that a traditional extraction
separation method is difficult in purified
product recovery, low in selectivity, low in efficiency and the like are solved.