The invention discloses a comprehensive prevention and treatment method for honey pomelo scabs. The comprehensive prevention and treatment method comprises the steps of fruit tree treatment, soil texture adjustment, physical prevention and treatment, and pesticide prevention and treatment. According to the method, a trunk is warped upwards, a distance is remained, ventilation and light transmission are convenient, fruit thinning enables honey pomelos to grow more fully, the fruit drop rate is reduced, and breathable transparent film bag are matched to avoid contact propagation of diseases andpests; a drainage channel and a reflective mulching film are matched with physical prevention and treatment of terrains, so that orchards can be kept dry and the bottoms of fruit trees can be lighted,fungus propagation infection in a humid environment is prevented, scab morbidity is reduced, and weeding and soil loosening are carried out to loosen and ventilate soil; deeply-buried organic fertilizer, ground surface inorganic fertilizer, a low-toxicity bactericide, an antibacterial agent mixed material, brassin and micro element fertilizer are matched, soil fertility is improved, ground is dried, bacterial and fungal viruses in the orchards are effectively killed, the resistance of the fruit trees is improved, the yield is stably increased, the scab morbidity is reduced to the minimum in cooperation with pesticide prevention and treatment, and at the same time, the scabs can be prevented from further spreading to stop loss in time.