Ophthalmic drug delivery device

A technology for releasing devices and drugs, applied in the field of implants, can solve problems such as increased bleeding and accumulation of subretinal fluid, increased blood flow of choroidal hyperemia, etc.

Inactive Publication Date: 2007-10-10
ALCON INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent application reveals that this pressure increases choroidal hyperemia and blood flow through the subretinal neovascularization membrane, which in turn increases hemorrhage and accumulation of subretinal fluid

Method used

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  • Ophthalmic drug delivery device
  • Ophthalmic drug delivery device
  • Ophthalmic drug delivery device

Examples

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Embodiment Construction

[0036] The preferred embodiment of the present invention and its advantages are best understood by referring to Figures 1 to 21 of the accompanying drawings, wherein like reference numerals will be used for like or corresponding parts in the various figures.

[0037]Figures 1 to 6 illustrate parts of the human eye that are important to understanding the present invention. Referring to Figure 1, a human eye 90 is schematically shown. Eye 90 has a cornea 92 , a lens 93 , vitreous body 95 , a sclera 100 , a choroid 99 , a retina 97 and an optic nerve 96 . The eye 90 is generally divided into an anterior portion 89 and a posterior portion 88 . Front portion 89 of eye 90 includes the portion of eye 90 that is forward of ora serrata 11 . The rear portion 88 of the eye 90 generally includes the portion of the eye 90 behind the ora serrata 11 . The retina 97 is physically connected to the choroid 99 in a circumferential manner, proximal to the ciliary annulus 13 behind the optic di...

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Abstract

The present invention is directed to a drug delivery device for a human eye. The human eye has a sclera, an inferior oblique muscle, and a macula. The device of the present invention includes a pharmaceutically active agent, and a geometry that facilitates the implantation of the device on an outer surface of the sclera, beneath the inferior oblique muscle, and with the pharmaceutically active agent disposed above the macula. Methods of delivery a pharmaceutically active agent to the posterior segment of the human eye are also disclosed.

Description

[0001] This application claims the benefit of US Provisional Application Serial No. 60 / 160,673, filed October 21, 1999, entitled "Drug Release Device," which provisional application is incorporated herein. technical field [0002] The present invention generally relates to biocompatible implants for the local release of pharmaceutically active agents into body tissue. More particularly but not limitedly, the present invention relates to biocompatible implants for the local release of pharmaceutically active agents to the back of the eye. Background technique [0003] Several diseases of the back of the eye threaten vision. Age-related macular degeneration (ARMD), choroidal neovascularization (CNV), retinopathy (eg, diabetic retinopathy, vitreoretinopathy), retinitis (eg, cytomegalovirus retinitis (CMV)), uvea Inflammation, macular edema, glaucoma and neuropathy are a few examples of these diseases. [0004] Age-related macular degeneration (ARMD) is the leading cause of ag...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F9/00A61K9/00A61M37/00A61F9/007
CPCA61K9/0051A61F9/0017A61F9/00781A61F2/14A61F2009/00891A61F2250/0067
Inventor 约瑟夫·雅各比
Owner ALCON INC
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