Novel levamisole formulation for chronic rhinitis

A technology for chronic rhinitis and levamisole, applied in the field of levamisole nasal drops, can solve the problems of vitamin deficiency, obstacles, affecting the vasomotor and contraction of nasal mucosa, and achieve the effect of relieving inflammatory symptoms and relieving symptoms

Inactive Publication Date: 2008-01-30
JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] (2) Vitamin deficiency, such as vitamin A or C
[0012] (3) Excessive smoking and alcohol can affect nasal mucosal vasomotor and cause obstacles
[0

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0053] Example 1 Levamisole spray to treat chronic rhinitis

[0054] Levamisole was used to treat 105 cases of chronic rhinitis and achieved remarkable clinical effects.

[0055] General Information There are 217 outpatient cases, including 142 males and 75 females; the age range is 16 to 44 years, with an average of 27 years. The patient's course of illness was 13 months to 12 years. There were 63 cases of chronic simple rhinitis and 154 cases of chronic hypertrophic rhinitis. All cases have received drug treatment, 11 cases have received cryotherapy, 23 cases have received laser treatment, and 17 cases have received inferior turbinate drug injection. The drug is unknown.

[0056] Treatment method Patients were randomly divided into levamisole treatment group (105 cases, including 36 cases of chronic simple rhinitis and 69 cases of chronic hypertrophic rhinitis) and control group (112 cases, including 27 cases of chronic simple rhinitis and 85 cases of chronic hypertrophic rhiniti...

Example Embodiment

[0062] Example 2 Treatment of Chronic Rhinitis with Levamisole Aerosol

[0063] Repeat the experiment described in "Example 1", except that levamisole aerosol (dose of 70ug / 0.14ml per spray) was used as the therapeutic agent and the condition and number of patients observed were different, the criteria for patient admission, treatment plan, The curative effect judgment standard is the same as "Example 1", and the experimental results are similar to "Example 1", that is, levamisole aerosol is used to treat chronic rhinitis, and its curative effect is better than 0.25% chloramphenicol ephedrine solution.

Example Embodiment

[0064] Example 3 Treatment of chronic rhinitis with levamisole nose drops

[0065] Repeat the experiment described in "Example 1", except that the treatment is levamisole nasal drops (concentration 350ug / ml), the method of administration is to change each spray of the spray to each nasal drip and observe the patient’s condition Except for the difference in number, the criteria for enrollment, treatment plan, and efficacy judgment of patients are the same as in "Example 1", and the experimental results are similar to "Example 1", that is, levamisole nasal drops are used to treat chronic rhinitis, and its efficacy is better than 0.25 % Chloramphenicol ephedrine solution.

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PUM

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Abstract

Said invention relates to spraying agent, aerosol, atomized powder agent and nasal drop which are all made of levamisole and used for curing bull nose.

Description

technical field [0001] The invention relates to levamisole nasal drops, levamisole nasal spray and levamisole nasal aerosol for treating chronic rhinitis and their application. Background technique [0002] 1. Introduction to chronic rhinitis| [0003] Chronic rhinitis is chronic inflammation of nasal mucosa and submucosa. It manifests as chronic congestion and swelling of the nasal mucosa, which is called chronic simple rhinitis. If it develops into hyperplasia and hypertrophy of nasal mucosa and turbinates, it is called chronic hypertrophic rhinitis. [0004] (1) Etiology [0005] 1. Local etiology [0006] (1) Acute rhinitis develops into chronic rhinitis due to repeated attacks or incomplete treatment. [0007] (2) Poor ventilation or drainage obstruction in the nose due to long-term stimulation or deformity of adjacent chronic inflammation, such as chronic sinusitis, deviated nasal septum, chronic tonsillitis or adenoid hypertrophy. [0008] (3) Rhinitis medicamen...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61K9/12A61K9/72A61P11/02
Inventor 郑文婕王鹤尧
Owner JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD
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