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Novel levamisole formulation for chronic rhinitis

A technology for chronic rhinitis and levamisole, applied in the field of levamisole nasal drops, can solve the problems of vitamin deficiency, obstacles, affecting the vasomotor and contraction of nasal mucosa, and achieve the effect of relieving inflammatory symptoms and relieving symptoms

Inactive Publication Date: 2008-01-30
JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] (2) Vitamin deficiency, such as vitamin A or C
[0012] (3) Excessive smoking and alcohol can affect nasal mucosal vasomotor and cause obstacles
[0045] 5. So far, there have not been any reports or literature records on the use of levamisole for the treatment of chronic rhinitis at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1 Levamisole spray treats chronic rhinitis

[0054] 105 cases of chronic rhinitis were treated with levamisole, and significant clinical effects were obtained.

[0055] General information 217 outpatient cases, including 142 males and 75 females; aged 16 to 44 years, with an average of 27 years old. The patient's course of disease ranged from 13 months to 12a. There were 63 cases of chronic simple rhinitis and 154 cases of chronic hypertrophic rhinitis. All cases had received drug treatment, 11 cases had received cryotherapy, 23 cases had received laser treatment, 17 cases had received inferior turbinate drug injection, the drug is unknown.

[0056] Treatment method Patients were randomly divided into levamisole treatment group (105 cases, including 36 cases of chronic simple rhinitis and 69 cases of chronic hypertrophic rhinitis) and control group (112 cases, including 27 cases of chronic simple rhinitis and 85 cases of chronic hypertrophic rhinitis) ). Th...

Embodiment 2

[0062] Embodiment 2 Levamisole aerosol treatment chronic rhinitis

[0063] Repeat the experiment described in "Example 1", except that what the therapeutic drug has adopted is levamisole aerosol (dosage is 70ug / 0.14ml every spray) and the observed patient's condition and the number are different, the patient's enrollment standard, treatment plan, Curative effect judgment standard is all the same as " embodiment 1 ", and experimental result is similar with " embodiment 1 ", promptly adopts levamisole aerosol to treat chronic rhinitis, and its curative effect is better than 0.25% chloramphenicol ephedrine liquid.

Embodiment 3

[0064] Embodiment 3 Levamisole nasal drops treats chronic rhinitis

[0065] Repeat the experiment described in "Example 1", except that what the therapeutic drug adopts is levamisole nasal drops (concentration is 350ug / ml), and the method of administration is to change every spray of spray into nasal drops and the patient's condition of observation Except for the difference in number, the patient enrollment criteria, treatment plan, and curative effect judgment criteria are the same as "Example 1", and the experimental results are similar to "Example 1", that is, using levamisole nasal drops to treat chronic rhinitis, its curative effect is better than 0.25 % chloramphenicol ephedrine solution.

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PUM

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Abstract

Said invention relates to spraying agent, aerosol, atomized powder agent and nasal drop which are all made of levamisole and used for curing bull nose.

Description

technical field [0001] The invention relates to levamisole nasal drops, levamisole nasal spray and levamisole nasal aerosol for treating chronic rhinitis and their application. Background technique [0002] 1. Introduction to chronic rhinitis| [0003] Chronic rhinitis is chronic inflammation of nasal mucosa and submucosa. It manifests as chronic congestion and swelling of the nasal mucosa, which is called chronic simple rhinitis. If it develops into hyperplasia and hypertrophy of nasal mucosa and turbinates, it is called chronic hypertrophic rhinitis. [0004] (1) Etiology [0005] 1. Local etiology [0006] (1) Acute rhinitis develops into chronic rhinitis due to repeated attacks or incomplete treatment. [0007] (2) Poor ventilation or drainage obstruction in the nose due to long-term stimulation or deformity of adjacent chronic inflammation, such as chronic sinusitis, deviated nasal septum, chronic tonsillitis or adenoid hypertrophy. [0008] (3) Rhinitis medicamen...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61K9/12A61K9/72A61P11/02
Inventor 郑文婕王鹤尧
Owner JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD
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