Application of steroidal sapogenins and their derivatives in medicine preparation

A use, technology of smilagenin, applied in the field of membrane-bound receptors and their functions

Inactive Publication Date: 2008-04-02
PHYTOPHARM LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are deficiencies in the three conventional therapeutic approaches mentioned above for the treatment of AD / SDAT: complementation of ACh precursors, replacement of agonists and inhibition of acetylcholinesterase
However, this compound can cause unacceptable cholinergic side effects such as fatigue, diarrhea and nausea

Method used

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  • Application of steroidal sapogenins and their derivatives in medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0099] Example - Study of mRNA levels using in situ hybridization

[0100] Pure male SD rats aged 20 months were randomly divided into 2 groups. One group received an average of 3 mg smilagenin / rat / day mixed into the daily diet. The control group received normal food and water. After 4 months, their brains were used for hybridization experiments, and rats aged 4-6 months were used as a young control group. The other feeding arrangements for each group were exactly the same.

[0101] synthesized respectively relative to m 1 and m 2 cDNA strand of mRNA. m 1 It is equivalent to the 3-18 amino acids of the receptor protein amino acid sequence, that is, TGG TGC CAA GAC AGT GAT GTT GGG ACT GAC AGC AGGGGG CAC TGA GGT and M 2 It is equivalent to the amino acid sequence of positions 1-16, that is, ATG AAT AAC TCA ACA AACTCC TCG AAC AAT GGC TTG GCT ATT ACC AGT. Use with a- 35 S-dATP (8.9TBq / mmol) was used as a 3'-end labeling kit to label cDNA. After the reaction is complete...

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Abstract

The invention discloses one or more applications of non-steroidal estrogen of saponins or saponin elements for preparing combinations treating the Parkinson's disease, except to the saponin elements and saponins which can effectively impact a retractile force of myocardium, the material can directly or non-directly adjust functions of the cytoplasm, the nucleolus, the membrane-binding protein or acceptors. When the protein or accepters are activated by the agonist that combines them, or the activity is promoted by making the antagonist deactivation, it can increase and / or normalize the organizations, organs, cell types or amount and / or turnover of the membrane receptor combination in the cellular organ.

Description

technical field [0001] This application is a divisional application of the Chinese application with application number 99806158.1. [0002] The present invention relates to membrane bound receptors and their functions, cognitive dysfunction and similar diseases, methods of treatment thereof and compositions useful in such methods of treatment. More particularly, but not exclusively, the invention also relates to methods of treating diseases characterized by deficiencies in the number or function of membrane-bound receptors. In the following, the invention is mainly described with reference to Alzheimer's disease (AD) and senile dementia of the Alzheimer's type (SDAT), in which a large number of receptor-type defects have been demonstrated. However, it is to be understood that the present invention generally relates to methods of treating diseases resulting from pathological conditions in vivo and / or exposure to adverse environmental conditions which manifest as defects in the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61K31/56A61K31/7048A61K31/704A61P9/02A61P21/04A61P25/16A61P39/02A61P39/06A61P43/00C12N15/09A61KA61K31/343A61K31/352A61K31/70A61K35/00A61K36/18A61K36/896A61P9/00A61P25/18A61P25/28C07D493/10C07J71/00C12Q1/68G01N33/94
CPCA61K36/8965A61K31/704A61K36/90A61K31/7048A61K31/58A61K36/896G01N33/944A61K36/8964A61K36/88A61P21/04A61P25/00A61P25/16A61P25/18A61P25/28A61P39/00A61P39/02A61P39/06A61P43/00A61P9/00A61P9/02A61K35/00
Inventor 夏宗勤胡亚尔I·罗宾J·布罗斯托夫B·惠特尔王维军P·冈宁
Owner PHYTOPHARM LTD
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