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Membrane-bound protein. A protein that is part of a cell membrane and acts as a receptor for substances transported in extracellular fluid or as an agent that mediates the transport of chemicals into or out of the cell.
Downregulation of membrane-bound proteins by receptor TAC technology
ActiveEP4178986B1Antibody mimetics/scaffoldsImmunoglobulins against cell receptors/antigens/surface-determinantsReceptorMembrane bound protein
Provided are novel fusion proteins, nucleic acids encoding said proteins, vectors comprising said nucleic acids, compositions comprising said nucleic acids or vectors, host cells comprising said nucleic acids, vectors or compositions or pharmaceutical compositions. Provided are methods of reducing (down regulating) a target membrane-bound protein (MBP) level in a cell, methods of producing a cell having a reduced target membrane-bound protein level, or methods of treating a disease, or methods of reducing or preventing GvHD in a subject associated with the administration of one or more CAR T-cells to the subject.
Owner:SHANDONG BIOANTY BIOLOGICAL TECH CO LTD +1