3 results about "Membrane bound protein" patented technology

Provided are novel fusion proteins, nucleic acids encoding said proteins, vectors comprising said nucleic acids, compositions comprising said nucleic acids or vectors, host cells comprising said nucleic acids, vectors or compositions or pharmaceutical compositions. Provided are methods of reducing (down regulating) a target membrane-bound protein (MBP) level in a cell, methods of producing a cell having a reduced target membrane-bound protein level, or methods of treating a disease, or methods of reducing or preventing GvHD in a subject associated with the administration of one or more CAR T-cells to the subject.

A method of expanding natural killer cells, comprising: providing a population of internal colloidal cells, wherein each internal colloidal cell comprises an internal colloidal volume and a fluid cell membrane comprising one or more membrane-bound proteins, each or collectively of which is capable of stimulating expansion of natural killer (NK) cells; and culturing a population of cells comprising NK cells capable of responding to the one or more membrane-bound proteins with the population of internal colloidal cells under conditions that allow expansion of the NK cells.