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Osmotic pump type controlled release preparation of kurarinone and its preparing method

A technology of osmotic pump controlled release and matrine, applied in antiviral agents, pharmaceutical formulations, digestive system, etc., can solve problems such as difficulty in industrialized large-scale production, difficulty in controlling drug release rate, and large batch-to-batch variance of products. To achieve the effect of reducing toxic and side effects, convenient administration and taking, and long-lasting effect

Inactive Publication Date: 2008-09-03
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Matrine has excellent water solubility, and it is not easy to control the drug release rate. The main difficulty is to control the stable release of the drug for a long time. On the other hand, the difference between batches of products is large, and it is not easy to carry out large-scale industrial production.

Method used

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  • Osmotic pump type controlled release preparation of kurarinone and its preparing method
  • Osmotic pump type controlled release preparation of kurarinone and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Tablet Prescription:

[0031] Matrine 300.0g

[0032] Sodium chloride 200.0g

[0033] Lactose 77.0g

[0034] Magnesium Stearate 3g

[0035] Preparation of tablet cores: crush the prescribed amount of medicine, sodium chloride, and lactose, sieve, mix evenly, use 95% ethanol as a wetting agent to make a soft material, granulate with a 20-mesh sieve, and dry the wet granules at 50±5°C. Sieve with 18 meshes, mix the dry granules with a lubricant, and press into tablets to obtain 1000 tablet cores.

[0036] Coating Solution Prescription:

[0037] Cellulose acetate 100g

[0038] PEG6000 12g

[0039] Dibutyl phthalate 13mL

[0040] Acetone 5L

[0041] Coating process: put the tablet core in the coating pan, blow in hot air, and coat the tablet core when the temperature is about 40°C. The flow rate of the coating solution is 5-10mL / min, and the pressure is 0.8kg / cm2 , the temperature in the coating pan is about 40°C, until the thickness of the outer coating film of th...

Embodiment 2

[0043] Tablet Prescription:

[0044] Matrine 300.0g

[0045] Sucrose 100.0g

[0046] Lactose 177.0g

[0047] Magnesium Stearate 3g

[0048] Tablet core preparation, with embodiment 1:

[0049] Coating Solution Prescription:

[0050] Cellulose acetate 100g

[0051] PEG6000 12g

[0052] Dibutyl phthalate 5mL

[0053] Acetone 5L

[0054] Coating process, with embodiment 1.

Embodiment 3

[0056] Tablet Prescription:

[0057] Matrine 300.0g

[0058] Sodium chloride 200.0g

[0059] Pregelatinized starch 77.0g

[0060] Magnesium Stearate 3g

[0061] Tablet core preparation: same as in Example 1.

[0062] Coating liquid prescription: with embodiment 1.

[0063] Coating process: with embodiment 1.

[0064] The matrine osmotic pump type controlled release preparation of the present invention is characterized in that: the film-forming material is cellulose acetate, the plasticizer is PEG1500, PEG4000, PEG6000, phthalate, glyceride, succinate, benzoate Ester, phosphate, adipate, tartrate, citrate, etc., the coating solvent is acetone, acetone and isopropanol, acetone and chloroform and other mixed solvents, coating process: the flow rate of the coating solution is 5-10mL / min, the pressure is 0.8kg / cm 2 , the temperature inside the coating pan is about 40°C, the rotation speed of the coating pan is 10-20rpm, and the diameter of the perforation is 0.4-0.6mm.

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Abstract

A release controlled osmotic pump type kurarinol is prepared from kurarinol, diluent, osmosis promoter, lubricant and adhesive through pulverizing, sieving, mixing, adding alcohol, granulating, drying, adding lubricant, talbetting, and coating. Its advantages are long time for maintaining effective blood concentration, and less peak and valley of blood concentration.

Description

Technical field: [0001] The invention relates to a new pharmaceutical dosage form of matrine, specifically, it is a osmotic pump type controlled release preparation of matrine and a preparation method thereof. Background technique: [0002] Matrine is an active ingredient extracted from the traditional Chinese medicine Sophora alopecuroides L or Sophora flavescens Ait, and the content of oxymatrine (Oxymatrine) is more than 98%. Pharmacological and clinical studies have shown that it has anti-tumor , antibacterial, antiviral, improve liver function and prevent liver fibrosis, reduce transaminase, improve the body's immunity and so on. At present, matrine has been identified as a key promotional engineering drug for the treatment of viral hepatitis. It can significantly inhibit the infection of hepatitis B virus. According to quantitative gene detection, after using matrine, the replication level of hepatitis B virus in infected cells is significantly reduced, which shows tha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4375A61K9/22A61P35/00A61P31/04A61P31/12A61P1/16
Inventor 何仲贵唐景玲
Owner SHENYANG PHARMA UNIVERSITY
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