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Derivative tendon stent material and its preparing process

A technology for scaffold materials and tendons, applied in the field of preparation of tendon scaffold materials, can solve the problems of failing to achieve tendon biomechanical characteristics and histocompatibility, unfavorable tissue cell growth, reproduction and secretion of extracellular matrix, etc., to achieve favorable growth , no chemical residues, less immune response

Inactive Publication Date: 2008-10-08
曲彦隆
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem that the absorbable and degradable polyester biochemical materials cannot meet the biomechanical characteristics and histocompatibility of the tendon of normal people, the immunoreactivity of the allogeneic tendon scaffold is large and these two tendon scaffolds are not conducive to the growth of tissue cells , reproduction and secretion of extracellular matrix, and provide a preparation method of derived tendon scaffold material

Method used

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  • Derivative tendon stent material and its preparing process
  • Derivative tendon stent material and its preparing process
  • Derivative tendon stent material and its preparing process

Examples

Experimental program
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specific Embodiment approach 1

[0007] Embodiment 1: The tendon scaffold derived from this embodiment is made of animal or human tendon as raw material.

specific Embodiment approach 2

[0008] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the derived tendon scaffold material is made of mammalian or human tendon as raw material.

specific Embodiment approach 3

[0009] Specific Embodiment Three: In this embodiment, the preparation of the derived tendon scaffold material is realized through the following steps: (1) cutting animal or human tendon for pretreatment, and then soaking it in a mixture of glycerin and MEM; (2) soaking the tendon Place the tendon in a sealed container and freeze at -80 to -90°C for 10±1 days; (3) Vacuum freeze-drying: reduce the water content of the tendon at -30 to -60°C and 0.03 to 0.1kpa. to 5% to 10%; (4) physical twisting and splitting treatment; (5) soaking and shaking in hydrogen peroxide; (6) immersing in distilled water at room temperature for 2 to 4 times, each time for 25 to 35 minutes; (7) vacuum again Freeze-drying: at -30~-60 ℃, the moisture content of tendon is reduced to 5%~10% under the condition of 0.03~0.1kpa; (8) seal, then use 1~10mGry strength Co 60 - Sterilization by gamma ray to obtain the derived tendon scaffold material.

[0010] The derived tendon scaffold material prepared in this ...

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Abstract

The invention discloses a derivatized tendon rack material and making method, which comprises the following steps: (1) cutting animal or human tendon to predispose; immersing the tendon in the composite liquid of glycerin and MEM; (2) freezing at -80- -90 deg.c for 10+-1d; (3) freezing to dry in the vacuum; (4) twisting physically; dividing; (5) immersing through hydrogen peroxide; vibrating; (6) washing through distilled water under indoor temperature; (7) freezing to dry in the vacuum again; (8) sealing; sterilizing through Co60-gamma ray; obtaining the product.

Description

technical field [0001] The invention relates to a preparation method of a tendon support material. Background technique [0002] In the past, absorbable and degradable polyester biochemical materials could not achieve the biomechanical characteristics and tissue compatibility of normal human tendon, and the allogeneic tendon scaffold had a large immune response, which was not ideal. And these two tendon scaffolds are not conducive to the growth, reproduction and secretion of extracellular matrix of tissue cells. Contents of the invention [0003] The purpose of the present invention is to solve the problem that the absorbable and degradable polyester biochemical materials cannot meet the biomechanical characteristics and histocompatibility of the tendon of normal people, the immunoreactivity of the allogeneic tendon scaffold is large and these two tendon scaffolds are not conducive to the growth of tissue cells , reproduction and secretion of extracellular matrix, and pro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/38
Inventor 曲彦隆
Owner 曲彦隆