Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Extraction method of polygala refined total saponin

An extraction method and a technology of total saponins, which are applied in chemical instruments and methods, pharmaceutical formulas, preparation of sugar derivatives, etc., can solve the problems of high cost, high risk of industrial production, unfavorable industrial production, etc., and achieve the effect of increasing the net content

Inactive Publication Date: 2009-04-22
徐东铭
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Not only that, the previous preparation process still has the use of organic solvents in the extraction process, resulting in high cost and high risk of industrial production, which is not conducive to industrial production

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 3

[0033] Example 3: Preparation of Polygala Refined Total Saponins Capsules.

[0034] 1. Take Polygala 1kg and add 22kg of water, heat and boil 3 times, 1.5 hours each time;

[0035] 2. Collect and combine the obtained water extracts, concentrate to a relative density of 1.20 at 80°C;

[0036] 3. Add ethanol to the concentrated solution to make the ethanol content in the solution reach 65%, filter, and reclaim ethanol from the filtrate;

[0037] 4. Add 2% medicinal activated carbon to the filtrate, heat and reflux for 15 minutes, decolorize and filter;

[0038] 5. Adjust the pH value of the above filtrate to 12, place it, and filter;

[0039] 6. Pass the filtrate through the D21 macroporous adsorption resin column, elute the resin column with 20% ethanol, elute separately until the eluent is colorless, discard the eluent, elute the resin column with 70% ethanol, collect the washed Dehydration;

[0040] 7. Pass the 70% ethanol eluent through an anion resin column, recover the...

Embodiment 4

[0042] Example 4: Preparation of Oral Dosage of Refined Polygala Total Saponins.

[0043] 1. Take Polygala 1kg, add appropriate amount of 18kg of water, heat and boil 3 times, 1.5 hours each time;

[0044] 2. Collect and combine the obtained water extracts, concentrate to a relative density of 1.15 at 80°C;

[0045] 3. Add ethanol to the concentrated solution to make the ethanol content in the solution reach 70%, filter, and reclaim ethanol from the filtrate;

[0046] 4. Add 2% medicinal activated carbon to the filtrate, heat and reflux for 30 minutes, decolorize and filter;

[0047] 5. Adjust the pH value of the above filtrate to 11, place and filter;

[0048] 6. Pass the filtrate through the AB-8 macroporous adsorption resin column, elute the resin column with 30% ethanol, elute separately until the eluent is colorless, discard the eluent, and elute the resin column with 65% ethanol, Collect eluate;

[0049] 7. Pass the 65% ethanol eluent through an anion resin column, r...

Embodiment 5

[0051] Example 5: Preparation of Polygala Refined Total Saponins Dropping Pills.

[0052] 1. Take Polygala 1kg and add 22kg of water, heat and boil 3 times, 1.5 hours each time;

[0053] 2. Collect and combine the obtained water extracts, concentrate to a relative density of 1.20 at 80°C;

[0054] 3. Add ethanol to the concentrated solution to make the ethanol content in the solution reach 65%, filter, and reclaim ethanol from the filtrate;

[0055] 4. Add 2% medicinal activated carbon to the filtrate, heat and reflux for 30 minutes, decolorize and filter;

[0056] 5. Adjust the pH value of the above filtrate to 12, place it, and filter;

[0057] 6. Pass the filtrate through the D21 macroporous adsorption resin column, elute the resin column with 10% ethanol, and elute separately until the eluent is colorless, discard the eluent, elute the resin column with 70% ethanol, collect the washed Dehydration;

[0058] 7. The 70% ethanol eluate is passed through an anion resin colu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A process for extracting general saponin from polygala root and refining it includes such steps as crushing, decocting, concentrating, adding alcohol, filtering, recovering alcohol, regulating pH=8-14, laying aside, filtering, flowing through macroreticular adsorption resin, alcohol eluting, flowing through ionized resin and decoloring resin, concentrating, drying to obtain dried powder, dissolving in alcohol, adding medicinal activated carbon, thermal reflux, filtering, vacuum recovery of alcohol, and concentrating to obtain dried powder.

Description

Technical field: [0001] The invention belongs to the field of pharmacy, and in particular relates to an extraction of high-purity polygala total saponins and a drug preparation in which the extract is the basic activity. Background technique: [0002] Polygala (poligala tenuifolia Willd.) is a traditional Chinese medicine that has been developed and used for a long time. It has the functions of expectorant and sedative, anticonvulsant, antihypertensive, antimutagenic, anticancer and antibacterial. Previous studies have shown that the active pharmaceutical substance in Polygala is total saponins of Polygala, but the current extraction method of Total Saponins of Polygala does not apply a process with high extraction efficiency, nor does it use a very effective method to precipitate impurities. The total saponin content of polygala total saponin produced by the general macroporous adsorption resin method is on the low side, and the total saponin content in the extract only rea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/69C07H1/08A61P11/10A61P25/20A61P9/12A61P35/00A61P31/04
Inventor 徐东铭徐雅娟
Owner 徐东铭
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com