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Organ preservation liquid, preparation method and use thereof

A technique for organ preservation solution and preservation solution, which is applied in the fields of biology and medicine, and can solve the problems of inability to reduce

Inactive Publication Date: 2009-07-08
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] However, at present, this kind of preservation solution is only from how to preserve the activity of cells in the tissue, and cannot reduce the graft-versus-host or host-versus-graft reaction in the process of organ transplantation, thereby improving the survival rate after organ transplantation

Method used

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  • Organ preservation liquid, preparation method and use thereof
  • Organ preservation liquid, preparation method and use thereof
  • Organ preservation liquid, preparation method and use thereof

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preparation Embodiment 1～5

[0077] According to the formula shown in Table 1, the recombinant adenovirus expressing soluble TNF receptor and the recombinant adenovirus expressing soluble IL-1 receptor were added with 2% albumin and 40 U / L penicillin in sterile saline to prepare organ transplant preservation solutions a, b, c, d and e respectively.

[0078] Table 1 Formula of organ transplant preservation solution (calculated on the basis of 1 liter of preservation solution)

[0079] Example 1 Example 2 Example 3 Example 4 Example 5 expresses soluble TNF receptor type II

recombinant adenovirus (PFU)* 1.0×10 9 1.0×10 10 1.0×10 11 1.0×10 12 1.0×10 14 Expresses soluble IL-1 receptor type II

recombinant adenovirus (PFU)** 1.0×10 9 1.0×10 10 1.0×10 11 1.0×10 12 1.0×10 14 Albumin (grams) 20 50 100 200 50 NaCl(g) 9 9 9 9 9 Penicillin (grams) 40 40 40 40 40

[0080] *Recombinant adenovirus expressing type II soluble TNF rec...

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Abstract

The present invention provides an organ preservation solution and its preparation method and application. The preservation solution contains soluble TNF receptor and soluble IL-1 receptor or a carrier expressing the receptor. The application of the preservation solution can effectively reduce the host-versus-graft and graft-versus-host reactions in the process of organ transplantation, prolong the survival time of the graft, and improve the survival rate of the graft in the host body, so it can be effectively applied to organ transplantation, including Transplantation of vital organs such as kidneys, livers, and hearts.

Description

technical field [0001] The invention relates to the fields of biology and medicine, and more particularly relates to an organ preservation solution for organ transplantation and its preparation method and application. Background technique [0002] At present, organ transplantation is still an important means of treating certain diseases. However, after an organ is removed from a donor and then transplanted into a recipient, it often needs to be kept at a certain temperature. Therefore, in order to prolong the survival time of the graft and improve the survival rate of the graft in the host again, people often use the organ transplant preservation solution to preserve the transplanted organ. Since the rejection reaction during transplantation is related to various factors produced by the immune system, the relationship between various cytokines and immune rejection has always been the focus of research. [0003] TNF-α and IL-1 are the key factors mediating the alloimmune re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N1/02
Inventor 王建莉万涛王青青曹雪涛
Owner ZHEJIANG UNIV
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