Silktree albizzia general saponin and its extraction method, pharmaceutical use of the said composition and medicine preparation

A technology of total saponins and Albizia Julibrissin bark is applied in the field of pharmaceutical preparations to achieve the effect of improving immunity

Inactive Publication Date: 2009-07-15
徐东铭 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there is no information that the total saponins of Albizia julibrissin is prepared into medicine so far. The inventor has confirmed through a large number of experimental studies that the total saponins of Albizia juliensis (including extracting from the bark of Albizia julibrissin and the flower of Albizia juliensis) has obvious antidepressant effect and antitumor effect. , hypnotic and sedative effects, completed the extraction of total saponins of Albizia julibrissin and the preparation of drugs with total saponins of Albizia julienne as the basic active ingredient

Method used

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  • Silktree albizzia general saponin and its extraction method, pharmaceutical use of the said composition and medicine preparation
  • Silktree albizzia general saponin and its extraction method, pharmaceutical use of the said composition and medicine preparation
  • Silktree albizzia general saponin and its extraction method, pharmaceutical use of the said composition and medicine preparation

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Embodiment 1

[0076] Embodiment 1 (preparation 1 of Albizia Julibrissin total saponins)

[0077] Take 1kg of Albizia Julibrissin skin, add appropriate amount of water, heat and boil three times (40 minutes each time). Collect and combine the obtained water extracts, filter, add the filtrate to a macroporous adsorption resin column (D101, D21, AB-8 can be selected for the model) treated with acid and alkali in advance, wash the column with deionized water until the eluate is free color, and then eluted with 70% ethanol. Collect the 70% ethanol eluate, recover it under reduced pressure, evaporate to dryness, dissolve the obtained concentrate in 70% ethanol, place it, and filter it. The filtrate is concentrated and dried under reduced pressure to obtain 50 g of total saponins of Albizia julienne in yellow powder form.

Embodiment 2

[0078] Embodiment 2 (preparation 2 of Albizia Julibrissin total saponins)

[0079] Take 1kg of Albizia Julibrissin skin or flowers, add appropriate amount of water, heat and boil three times (40 minutes each time). Collect and combine the resulting water extracts, concentrate to a relative density of 1.20, add ethanol until the alcohol concentration is 70%, or extract with 85% ethanol, filter, recover the ethanol until there is no alcohol smell, add the liquid to the pre-used acid and alkali-treated macroporous adsorption resin column, wash the column with deionized water until the eluate is colorless, and then elute with 80% ethanol. The 80% ethanol eluate was collected, recovered under reduced pressure, and evaporated to dryness to obtain 80 g of total saponins of Albizia julienne in the form of yellow powder.

Embodiment 3

[0080] Embodiment 3 (preparation 1 of Albizia Julibrissin total saponins injection)

[0081] Get 100g of total saponins of Albizia julibrissin, dissolve it with 75% ethanol to make 5% total saponins of Albizia juliensis, decolorize with activated carbon, filter, concentrate and dry under reduced pressure, add water for injection to make an aqueous solution containing 20 mg of total saponins of Albizia juliensis per ml, and use micro Filter through a pore filter membrane (ф0.20 μm) until clear, sterilize, aseptically dispense into vials, 5ml per bottle, freeze-dry in a freeze dryer, and obtain the product.

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Abstract

The total saponin of Albizia Julibrissin and its extraction method and medicinal use belong to the technical field of traditional Chinese medicine. The total saponins of Albizia Julibrissin are extracted from Albizia Julibrissin bark and Albizia Julibrissin flower by water or alcohol solution, purified by macroporous adsorption resin column, eluted with alcohol, concentrated into diffuse paste or dry powder, dissolved in alcohol, and recovered from alcohol. It is used for preparing medicines for treating depression, tumors, sedative hypnosis and improving immunity. The positive effect of this invention is that the medicinal active substance Albizia julibrissin total saponin has been obtained, and new medicines are provided for the treatment and health care of diseases such as anti-depression, anti-tumor, sleeping and sedation, and improving immunity.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to total saponins extracted from Albizzia julibrissin Durazz flower and bark, an extraction method, medicinal use and pharmaceutical preparations. Background technique: [0002] Albizzia julibrissin Durazz belongs to Ranunculaceae in plant taxonomy. Albizia Julibrissin contains triterpenoids, flavonoids, lignin compounds, alkaloids and polysaccharides. Through some pharmacological studies on the active ingredients of Albizia Julibrissin in recent years, we found that the extract of Albizia Juliensis has antidepressant, antitumor, hypnotic and sedative effects. [0003] However, there is no information that the total saponins of Albizia julibrissin is prepared into medicine so far. The inventor has confirmed through a large number of experimental studies that the total saponins of Albizia juliensis (including extracting from the bark of Albizia jul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61K31/704A61P25/24A61P25/20A61P35/00A61P37/04
Inventor 徐东铭徐雅娟刘平
Owner 徐东铭
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