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Needle biosensor based on carbon nano tube and manufacturing method thereof

A biosensor, carbon nanotube technology, applied in instruments, scientific instruments, measuring devices, etc., can solve the problems of small detection range, low sensor response sensitivity, clinical application limitations, etc., to improve electrical conductivity and catalytic ability, high detection Sensitivity, the effect of maintaining the preservation period

Inactive Publication Date: 2009-07-29
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The biggest problem facing biosensors using carbon materials as electrodes is that due to the weaker conductivity of carbon compared to metals, the response sensitivity of the sensor is low and the detection range is small, which limits its clinical application.

Method used

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  • Needle biosensor based on carbon nano tube and manufacturing method thereof
  • Needle biosensor based on carbon nano tube and manufacturing method thereof
  • Needle biosensor based on carbon nano tube and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] In this example of biosensor, carbon nanotubes, conductive graphite powder, and glucose oxidase are mixed evenly at a ratio of 50:50:1 (mass ratio), and then filled into a needle-shaped hollow tube 1 made of glass (inner diameter 0.5 mm), press forming 2 as a positive electrode, and at the same time, a gold layer 3 is formed on the outer wall of the hollow tube by vacuum sputtering as a negative electrode. The pointed end of the needle sensor is the detection end, which can be inserted into the skin and fixed; the other end of the sensor leads the electrical detection signal from the sensor through the specially manufactured conductive interface 4, and connects with external equipment through conductive wires 5, 6, 7. For signal reception and recording.

Embodiment 2

[0034] In this example of biosensor, carbon nanotubes, conductive graphite powder, and glucose oxidase are mixed evenly at a ratio of 1:1:5 (mass ratio), and then filled into a needle-shaped hollow tube 1 made of silicone rubber after adding an adhesive. (inner diameter of 0.4 mm), press forming 2 as a positive electrode, and simultaneously form a platinum layer 3 on the outer wall of the hollow tube by vacuum sputtering as a negative electrode. The pointed end of the needle sensor is the detection end; the other end of the sensor leads out the electrical detection signal from the sensor through the specially manufactured conductive interface 4, and connects with external equipment through conductive wires 5, 6, 7 for signal reception and recording .

Embodiment 3

[0036]In this example of biosensor, carbon nanotubes, conductive graphite powder, and glucose oxidase are mixed evenly at a ratio of 5:3:2 (mass ratio), and then filled into a needle-shaped hollow tube made of polyimide after adding an adhesive 1 Inner (inner diameter 0.3 mm), press forming 2 is used as a positive electrode, and at the same time, a platinum layer 3 is formed on the outer wall of the polyimide tube by a vacuum sputtering method as a negative electrode. The pointed end of the needle sensor is the detection end, which can be inserted into the skin and fixed; the other end of the sensor leads the electrical detection signal from the sensor through the specially manufactured conductive interface 4, and connects with external equipment through conductive wires 5, 6, 7. For signal reception and recording.

[0037] figure 2 It is the current response curve of the sensor to the glucose concentration in phosphate buffer (pH7). The test time is 200 seconds.

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Abstract

The invention discloses a carbon nanotube needle biosensor and a manufacturing method thereof. It has a hollow tube, a positive electrode is arranged inside the hollow tube, a negative electrode is arranged outside the hollow tube, and a conductive interface is arranged on the upper end of the hollow tube, which is connected with the positive electrode and the negative electrode. The invention is composed of a plurality of electrodes, wherein the positive electrode is made of carbon nanotubes, conductive graphite powder, biologically active substances and binders mixed and pressed in a certain proportion, and the negative electrode is made of conductive metal. A microneedle biosensor is formed in a hollow tube made of compatible material. The needle sensor described above can be inserted into the sample to be tested, and the dynamic change of the measured substance in the sample can be detected online. The carbon nanotubes used in the present invention are specially treated, which can not only effectively improve the reactivity and storage period of biological substances, but also significantly improve the detection range and detection sensitivity of the sensor.

Description

technical field [0001] The invention relates to a data acquisition component of a biological and medical detection instrument, in particular to a carbon nanotube-based needle biosensor capable of intervening in biological tissue and a manufacturing method thereof. technical background [0002] The electrochemical sensor is a device that detects the type and concentration of the reaction substance qualitatively and quantitatively with the electrical signal as the characteristic detection object. In addition to applications in traditional fields, electrochemical analysis methods are also widely used in the detection of biological samples, such as blood and urine, as a means of diagnosing diseases. In the clinical analysis of biological samples, the methods used include chemical methods, optical methods, electrical methods, nuclear magnetic methods, etc. Electrochemical methods are currently developing very rapidly. [0003] At present, the main sampling analysis method used i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/403G01N27/327
Inventor 管文军葛浣溪李红陈裕泉
Owner ZHEJIANG UNIV
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