Permanent implanted artificial bone and its preparation method

A kind of artificial bone and permanent technology, applied in bone implants, medical science, prosthesis, etc., can solve the problems of mechanical properties of human bones and artificial joints, insufficient bonding force between coating and substrate, coating strength and fracture Poor toughness and other problems to achieve the effect of making up for the difficulty of bearing large loads, solving mechanical compatibility problems, and overcoming poor strength and fracture toughness

Inactive Publication Date: 2009-08-12
SHENYANG POLYTECHNIC UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Implantation experiments in vivo have proved that hydroxyapatite coating can strongly promote the chemical bonding of bone, has a very high biocompatibility, can accelerate the growth of new bone, and has been used clinically, but the hydroxyapatite coating Coated human bones and artificial joints still have problems with mechanical properties
Such as the coefficient of thermal expansion of HA (15×10 -6 K -1 ) than titanium alloy (8.8×10 -6 K -1 ) is much larger, and the strength and fracture toughness of the coating are poor, and the bonding force between the coating and the substrate is not high enough. As an implant material, its long-term clinical effect is not ideal, especially for young patients and patients with high activity , higher failure rate, often requiring reoperation after several years

Method used

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  • Permanent implanted artificial bone and its preparation method
  • Permanent implanted artificial bone and its preparation method
  • Permanent implanted artificial bone and its preparation method

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Experimental program
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Effect test

Embodiment 1

[0074] Grind the 10mm×10mm×5mm NiTi substrate and the surface to be observed of the porous coating sample to a metallographic sample, wash and dry it with deionized water, and place it in a reagent bottle filled with 200mL, 37°C simulated human body fluid SBF solution After soaking, the SBF solution in the bottle is replaced every 2 days to keep the composition of the SBF soaking solution basically constant. The two samples soaked in the SBF solution were taken out at the same time regularly, washed with deionized water, and dried at 50°C. SEM-EDX was used to observe and analyze the deposition and composition of bone-like apatite on the surface of the sample, and Nicolet Fourier transform infrared Spectroscopic (FTIR) analysis of the chemical structure of the sediment.

[0075] The formation of bone-like apatite on biomaterials is a prerequisite for its osteoinductivity. Therefore, studying the factors that affect the formation of bone-like apatite in implant materials is an e...

Embodiment 2

[0078] Animal implantation experiments. The animals selected for the experiment were 2 18-month-old male rabbits with body weights of 6.5Kg and 6.3Kg respectively. Animals were fasted the night before surgery and water was deprived on the same day. Pentobarbital sodium narcotics were injected through the ear according to conventional methods, and routine disinfection was performed. According to previous research experience, the implantation site of the implant material affects the bone formation in the body. In order to successfully induce the production of bone cells, the muscles near the vertebrae of the back were selected as the implantation site. An incision about 8 cm long was made on the back of the rabbit, the skin and subcutaneous tissue were cut open, the muscle tissue was exposed, and the intermuscular space was separated. Two samples of NiTi alloy dense material and porous coating were implanted into the rabbit's back spine in groups. There were 8 parallel samples...

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Abstract

An artificial bone for permanent implantation, with solid NiTi shape memory alloy as the base material and a porous coating on the surface, characterized in that: the porous coating is prepared by laser reaction synthesis, and the coating and the matrix are in good contact Metallurgical bonding. The artificial bone prepared by the invention not only has the strength and modulus of the solid NiTi alloy artificial bone, but also has good biocompatibility.

Description

Technical field: [0001] The present invention relates to a permanent new artificial bone material preparation technology, and in particular provides a laser reaction synthesis porous bionic structure coating powder technology and formula, the porous coating prepared on the surface of NiTi shape memory alloy can significantly improve the shape of NiTi The biocompatibility of the memory alloy is beneficial to the fixation and long-term stable existence of the implant in human tissue. Background technique: [0002] The bone and joint system are the tissues and organs that bear the load of the human body. The repair and replacement materials after their defects should have high mechanical strength. Therefore, metal biomaterials have always been the main materials for orthopedic surgery and are widely used in hard tissues in medicine. Substitution, restoration and manufacture of medical devices. For surgical implant materials, as biocompatible metals or alloys Ti, Ti6A14V, Co-Cr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/28A61L27/06A61L24/04
Inventor 张松张春华
Owner SHENYANG POLYTECHNIC UNIV
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