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Calculus bovis detoxifying dropping pill, and its preparing method

A bezoar detoxification and bezoar technology, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of hepatic and intestinal first-pass effect bioavailability, which is not conducive to improving the ability of patients to seek medical treatment, and the physical harm of staff. , to achieve the effects of improving bioavailability, drug safety, and low labor intensity

Active Publication Date: 2009-09-23
JIANGXI JIMINKEXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
[0008] In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the human body. some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

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Embodiment Construction

[0034] The preparation method of Niuhuangjiedu dripping pills of the present invention will be further described with several groups of specific examples.

[0035] [Group 1: Trials with a single substrate]

[0036] 1. Preparation of medicinal extracts: According to the [Appendix], first prepare the dry powder of extracts containing active ingredients of 8 traditional Chinese medicines, such as bezoar, realgar, gypsum, rhubarb, scutellaria, platycodon, borneol, and licorice;

[0037] 2. Substrate: polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , polyethylene glycol 20000 , Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac;

[0038] 3. Proportion: take g or kg as unit, by weight, drug extract: matrix = 1:1~1:9;

[0039] 4. According to the process given in [Preparation Method] 4-7, Niuhuangjiedu dripping pills of different specifications can b...

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PUM

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Abstract

The invention discloses a pharmaceutical composition which has heat-clearing and detoxifying effects, and is used for the treatment of diseases such as fire-heat, swelling and pain in the throat, swelling and pain in the gums, sore mouth and tongue, red eyes and swelling and pain. The object of the present invention is to supplement the deficiencies of the existing oral pharmaceutical preparations used for the treatment of the above-mentioned diseases, and to provide a bezoar detoxification agent with high bioavailability, rapid drug release, rapid effect, high drug content, low price, and easy to carry Dropping pills. The Niuhuang Jiedu dripping pills involved in the present invention are prepared from the extracts containing active ingredients of 8 traditional Chinese medicines such as bezoar, realgar, gypsum, rhubarb, scutellaria, platycodon, borneol, and licorice as raw materials, and prepared together with a pharmaceutically acceptable carrier as a matrix. to make.

Description

technical field [0001] The present invention relates to a kind of medicine composition that has heat-clearing and detoxifying effect, and is used for the treatment of illnesses such as fiery heat, sore throat, gingival swelling and pain, aphtha of the mouth and tongue, red eyes and swelling and pain. An oral preparation of a pharmaceutical composition prepared from active ingredient extracts of 8 traditional Chinese medicines such as rhubarb, scutellaria baicalensis, bellflower, borneol, licorice, etc. as raw materials. Background technique [0002] According to the preparation method given under Niuhuangjiedu pills on page 386 of the Chinese Pharmacopoeia 2005 edition, Niuhuangjiedu pills are a kind of medicine that has the effect of clearing away heat and detoxifying. , an oral preparation for the treatment of conjunctival congestion, swelling and pain, etc., has been clinically verified and has definite curative effects. It is a commonly used drug for clinical and family ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K33/36A61K33/06A61K35/413A61K36/34A61K36/539A61K36/484A61K36/708A61P1/02A61P11/04
Inventor 曲韵智
Owner JIANGXI JIMINKEXIN PHARMA
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