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Application of carbenoxolone in preparation of medicine for treating cerebral vasospasm

A technology for cerebral vasospasm and carbenoxolone is applied in the application field of carbenoxolone in the preparation of medicines for the treatment of cerebral vasospasm, and can solve the problems of unsatisfactory curative effect of cerebral vasospasm and the like

Inactive Publication Date: 2007-08-08
洪涛 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Cerebral vasospasm is a serious complication after spontaneous subarachnoid hemorrhage. At present, there is no effective drug for the treatment of cerebral vasospasm (CVS). The existing drugs are mainly calcium ion antagonists (such as nimodipine). Drugs only prevent the formation of cerebral vasospasm, and are not satisfied with the curative effect on the established cerebral vasospasm, especially delayed cerebral vasospasm

Method used

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  • Application of carbenoxolone in preparation of medicine for treating cerebral vasospasm
  • Application of carbenoxolone in preparation of medicine for treating cerebral vasospasm

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Embodiment

[0028] Carbenoxacin Injection is prepared by using a method known in the art with physiological saline as a vehicle.

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Abstract

The invention relates to a method for using genbo acid to prepare the drug in the brain angiospasm treatment. The animal test has proved the effect of genbo acid on the treatment of brain angiospasm, while it can reduce the penetration of spaced connection, or close some connecting channels to restrain the transmission of ion flow, second message molecule and the current between cells, to reduce the number of smooth muscle cells in the contraction to restrain the contraction of smooth muscle cell.

Description

technical field [0001] The present invention relates to the invention field of medicine application, in particular to the application of carbenoxic acid in the preparation of medicines for treating cerebral vasospasm after spontaneous subarachnoid hemorrhage. Background technique [0002] Carbenoxolone (carbenoxolone) (chemical formula: C 34 h 48 o 7 Na 2 , molecular weight: 614.7) is a colorless powder, tasteless, soluble in water to form a yellowish liquid. [0003] There are two common uses for carbenoxic acid: [0004] 1. Gap junction blocker, used to reduce material conduction between cells, mainly used in experimental research on heart, embryo, tumor, etc. [0005] 2. For the clinical treatment of gastric ulcer (alias: raw gastric ketone). [0006] Cerebral vasospasm is a serious complication after spontaneous subarachnoid hemorrhage. At present, there is no effective drug for the treatment of cerebral vasospasm (CVS). The existing drugs are mainly calcium ion an...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P9/10
Inventor 洪涛王海涛王欢汪阳
Owner 洪涛
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