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Carbohydrase inhibitors derived from chestnut and use thereof

A carbohydrase inhibitor, plant technology, applied in the fields of alpha-amylase or alpha-glucosidase inhibitors, pharmaceutical compositions and food compositions

Active Publication Date: 2007-08-15
辻田隆广 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Given this, known inhibitors are not necessarily satisfactory

Method used

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  • Carbohydrase inhibitors derived from chestnut and use thereof
  • Carbohydrase inhibitors derived from chestnut and use thereof
  • Carbohydrase inhibitors derived from chestnut and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] Preparation Example 1 Chestnut astringent bark extract

[0089] Dried chestnut astringent skin is ground to prepare chestnut astringent skin powder. 2 L of 50% v / v aqueous acetonitrile solution was added to 100 g of chestnut astringent skin powder, followed by stirring at room temperature for 5 hours. Then, the mixture was centrifuged at 3000 g for 15 minutes, and the resulting supernatant was concentrated in a rotary evaporator and lyophilized to obtain 6.8 g of an aqueous acetonitrile extract of the bark of Chestnut Astringent (lyophilized product).

Embodiment 2

[0090] Preparation Example 2 Chestnut shell extract

[0091] Dried chestnut shells were ground to prepare chestnut shell powder. 100 g of chestnut shell powder was processed in the same steps as in Preparation Example 1, thereby obtaining 7.5 g of an aqueous acetonitrile extract of chestnut shell (lyophilized product).

preparation Embodiment 3

[0092] Preparation Example 3 Chestnut Leaf Extract

[0093] Dried chestnut leaves are ground to prepare chestnut leaf powder. 100 g of chestnut leaf powder was processed in the same procedure as in Preparation Example 1, thereby obtaining 21.0 g of chestnut leaf aqueous acetonitrile extract (lyophilized product).

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Abstract

The present invention provides a plant-derived carbohydrase inhibitor, wherein the inhibitor is effective for preventing or alleviating diabetes, or preventing obesity, and foods, drinks, and medicines containing the same. The present invention is accomplished by use of an alpha-amylase inhibitor or an alpha-glucosidase inhibitor as a carbohydrase inhibitor that is extracted from astringent skins of a chestnut using ethanol or aqueous ethanol solution. The present invention can also be accomplished by adding the carbohydrase inhibitor to a food or medical composition as an active ingredient for delaying saccharide digestion or absorption, suppressing a rise in postprandial blood glucose levels or blood insulin levels, or preventing obesity.

Description

technical field [0001] The present invention relates to carbohydrase inhibitors, especially alpha-amylase or alpha-glucosidase inhibitors, derived from fagaceous plants. In addition, the present invention also relates to various applications of carbohydrase inhibitors, and specifically relates to pharmaceutical compositions and food compositions utilizing the physiological effects of the inhibitors. Background technique [0002] Changes in modern lifestyles have led to an increase in the prevalence of diabetes. In Japan, the number of diabetic patients including potential diabetic patients is estimated to exceed 15,000,000. Most diabetics have type 2 diabetes. Type II diabetes is closely related to obesity, and causes chronic hyperglycemia and the like due to insulin resistance. Furthermore, type II diabetes causes complications such as retinopathy, nephritis and neurological disorders. Diet and exercise therapy are key elements in the prevention and treatment of type 2 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A23L1/30A61P3/04A61P3/10A61P43/00
CPCA61K36/49A23L1/31436A23L2/52A23L1/3002A23L33/105A23L13/426A61P1/00A61P1/04A61P1/12A61P13/12A61P15/08A61P17/00A61P21/04A61P25/18A61P25/26A61P27/02A61P27/12A61P3/00A61P3/04A61P35/00A61P43/00A61P9/04A61P9/08A61P9/14A61P3/10A61K36/18
Inventor 辻田隆广高久武司
Owner 辻田隆广
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