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Methods of treating demyelinating disorders

An ephrin and active technology, applied in the field of multiple sclerosis, can solve problems affecting the repair process and other issues

Inactive Publication Date: 2007-08-15
AVENTIS PHARMA INC
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Additionally suggesting that interference with the EphB1 signaling pathway may allow migration of oligodendrocyte progenitors into areas of damaged brain tissue and positively affect repair processes

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  • Methods of treating demyelinating disorders
  • Methods of treating demyelinating disorders
  • Methods of treating demyelinating disorders

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[0026] A series of EphB1 mRNA expression profiles were analyzed on various cell types to determine the tissues in which EphB1 mRNA was expressed and the relative expression levels.

[0027] EphB1 mRNA levels were found to be enriched in oligodendrocytes. Figure 1 is a bar graph depicting the relative expression levels of EphB1 mRNA in four cell types: mature oligodendrocytes ("OL"), oligodendrocyte progenitors ("OLP"), astrocytes, and small Glial cells. Measurement of EphB1 expression was performed using a real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay. RT-PCR is a well-established fluorescence-based quantitative assay of steady-state mRNA levels in the art. In the RT-PCR assay, EphB1 mRNA was reverse transcribed and amplified using PCR. PCR was performed using probes containing a fluorophore and a quencher specially designed so that the fluorophore dissociates from its quencher in each round of amplification such that the level of fluorescence inc...

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Abstract

Methods of identifying and using compounds capable of treating demyelinating disorders such as multiple sclerosis by inhibiting EphB1-mediated cell repulsion of CNS and PNS glial cells (oligodendrocytes and Schwann cells and progenitor cells within these lineages).

Description

technical field [0001] The present invention relates to the field of treatment of multiple sclerosis, in particular by inhibiting EphB1-mediated cellular rejection of CNS and peripheral glial cells (oligodendrocytes and Schwann cells) and progenitor cells within these lineages. The field of sexual sclerosis. Background technique [0002] All documents cited are hereby incorporated by reference in their entirety. [0003] The erythropoietin-producing hepatocellular ("Eph") receptors are a family of receptor tyrosine kinases that contain an extracellular domain as well as an intracellular tyrosine kinase domain, the The extracellular domain has a unique cysteine-rich motif as well as two fibronectin type III motifs (Connor RJ and Pasquale EB (1995) Oncogene 11:2429-381995), the intracellular tyrosine kinase The domain is involved in signal transduction (Vindis et al., J Cell Biol. 2003 Aug 18;162(4):661-71). Eph receptors are involved in neurodevelopment and physiology and ...

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Application Information

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IPC IPC(8): G01N33/68
Inventor K・尚德罗斯J・梅里尔S・纳特森
Owner AVENTIS PHARMA INC
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