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Dietary compositions for enhancing metabolism and reducing reactive oxygen species

A composition and animal technology, applied in the direction of additional food elements, organic active ingredients, medical preparations containing active ingredients, etc., can solve problems such as insufficient antioxidant activity

Active Publication Date: 2007-08-22
ELIXIRIN CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The addition of polyphenols to the combination of carnitine and lipoic acid solves the problem of insufficient antioxidant activity of food supplements described in US patent US5916912 and international application WO98 / 57627

Method used

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  • Dietary compositions for enhancing metabolism and reducing reactive oxygen species
  • Dietary compositions for enhancing metabolism and reducing reactive oxygen species

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Rat Morris water maze spatial memory test

[0034] Figure 1 depicts spatial memory in the water maze test in rats (Fischer 344 males) treated with carnitine, lipoic acid, with or without polyphenols. Rats treated with a combination of carnitine, lipoic acid and polyphenols had a 50% higher ability to master the water maze than those treated with a single component (the duration of the composition treatment was about as long as that of the control group (no treatment) group) 38% of the time, the time spent on carnitine, lipoic acid, and polyphenol treatment alone was 80%, 79%, and 82% of the control group, respectively). The Morris water maze spatial memory test requires rats to use external visual cues to find a submerged platform in a pond (Morris, R. 1984; J. Neurosci. Methods, 11: 47-60; Schenk, F. and Morris, R , Exp. Brain Res. 58:11-28, 1985). The rats in the test group (5 groups) were either fed with 0.5% (wt / vol) acetyl-L-carnitine aqueous solution, ...

Embodiment 2

[0035] The oxidation degree of embodiment 2DNA

[0036] Figure 2 shows that rats treated with carnitine, lipoic acid and / or polyphenols had reduced cellular oxidative stress as measured by DNA oxidation levels. The levels of oxidation in rats treated with carnitine, lipoic acid, and polyphenols were 41% of those in untreated rats. The oxidation levels of rats treated with carnitine, lipoic acid, and polyphenols alone were 112%, 82%, and 65% of those of untreated rats, respectively. The rats in the test group (5 in each group) were either fed with 0.5% (wt / vol) acetyl-L-carnitine aqueous solution, or fed with 1.0% (wt / vol) polyphenol aqueous solution, or fed with 0.2% (wt / wt) lipoic acid AIN93M diet (main feed), or a combination of the above three. The rats were acclimatized to the environment for one week before the test, and fed for 7 weeks before the test. Rats in the control group were fed only water and AIN93M diet. In order to analyze the degree of DNA oxidation, the ...

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Abstract

This invention relates to dietary compositions and to methods for modifying cellular metabolism, metabolic production of reactive oxygen species and the resulting level of reactive oxygen species. The invention is drawn to a composition comprising a combination of carnitine, lipoic acid and polyphenol, which has the effect of enhancing metabolism and reducing oxygen species at the same time. When the composition is fed to older animals, the animals will have improved metabolism at the cellular level and a reduction of oxidative stress. The invention is also drawn to a method of oral administration of carnitine, lipoic acid and polyphenol to a mammalian host, at an effective dose necessary to affect enhanced metabolic processes and reduced oxygen species in animals including humans.

Description

(1) Technical field [0001] The present invention relates to a food composition and methods of altering cellular metabolism, production of reactive oxygen species and levels of reactive oxygen species. (2) Background technology [0002] Numerous evidences show that reactive oxygen species cause cell damage through oxidation of cell membrane, cytoplasm, and chromosomal DNA. Damage caused by reactive oxygen species can have multiple consequences. The oxidation of the cell membrane reduces the level of unsaturated fatty acids, thereby reducing the fluidity of the membrane, the oxidation of the cytoplasm damages the activity of intracellular enzymes, and reduces the level of metabolism, and the oxidation of DNA increases the probability of gene mutation. Mechanisms of damage to these cells, alone or in combination, can lead to reduced tissue and organ function, ultimately negatively affecting health. [0003] Aging cells are known to have reduced levels of mitochondrial metabol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/385
CPCA23K1/1612A23K1/002A23K1/004A23K1/1609A23K1/1618A61K31/385A23K40/10A23K40/30A23K20/105A23K20/111A23K20/121
Inventor 刘诚
Owner ELIXIRIN CORP
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