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Extractive of east asia scorpion and medicine for preventing and / or curing oral epithelial carcinoma thereof

An oral epithelial and extract technology, applied in the field of East Asian scorpion extract and its prevention and/or treatment of oral epithelial cancer, can solve the problems of severe toxicity and achieve safety, prevention and/or treatment of oral epithelial cancer Effect

Inactive Publication Date: 2007-09-12
BIOCHEM ENG COLLEGE OF BEIJING UNION UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Now there have been in-depth studies on the anti-cancer effect of the East Asian scorpion scorpion venom extract and the anti-cancer polypeptide extracted from the scorpion venom, but the scorpion venom is similar to the snake venom neurotoxin, and the toxicity is very severe

Method used

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  • Extractive of east asia scorpion and medicine for preventing and / or curing oral epithelial carcinoma thereof
  • Extractive of east asia scorpion and medicine for preventing and / or curing oral epithelial carcinoma thereof
  • Extractive of east asia scorpion and medicine for preventing and / or curing oral epithelial carcinoma thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 178.7g of frozen live scorpion, remove the venom glands at the tail, and obtain 172.1g of scorpion body, grind it in liquid nitrogen, then add an equal volume of distilled water, stir and mix well, let it settle for 12 hours, and the upper solution is frozen in a vertical Centrifuge at 4°C, take the supernatant and freeze it at -20°C, put it in a vacuum freeze dryer, freeze-dry it at -40°C. 9.6 g of freeze-dried powder was obtained.

Embodiment 2

[0024] Weigh 300g of frozen live scorpion, remove the venomous glands at the tail, and obtain 279.5g of scorpion body, add an equal volume of distilled water, put it in a tissue grinder, and keep the upper solution in a vertical refrigerated centrifuge at 4°C, centrifuge, and take the supernatant- After freezing at 20°C, put it in a vacuum freeze dryer at -40°C, and freeze-dry to obtain 18.6 g of freeze-dried powder.

Embodiment 3

[0026] Weigh 279g of frozen live scorpion, remove the venomous glands at the tail, and obtain 255g of scorpion body, add an equal volume of 10% by volume sterile glucose solution, put it in a tissue masher, let it stand for 20 minutes, and let it settle, and put the upper solution in a vertical refrigerated centrifuge , 4°C, centrifuged, the supernatant was frozen at -20°C, placed in a vacuum freeze dryer, and freeze-dried at -40°C. 14 g of freeze-dried powder was obtained.

[0027] Prove that the East Asian scorpion scorpion extract of the present invention has cell line tests, animal tests, and toxicity tests for the prevention and / or treatment of oral epithelial cancer as follows:

[0028] Anti-oral epithelial cancer effect

[0029] 1. Cell line: human oral epithelial carcinoma KB cells (provided by the Institute of Materia Medica, Chinese Academy of Medical Sciences) are cultivated in RPMI1640 culture fluid containing 10% (weight percent) calf serum (containing penicillin...

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Abstract

The medicine for preventing and / or treating oral epithelial cancer consists of Scorpionidae extract and pharmaceutically acceptable carrier. The Scorpionidae extract is prepared through eliminating poison gland of Scorpionidae, grinding, adding distilled water or glucose solution via stirring, precipitating, centrifuging to obtain supernatant, and freeze drying to obtain freeze dried powder. The medicine may be prepared into different forms for preventing and / or treating oral epithelial cancer effectively, and is non-toxic and safe.

Description

technical field [0001] The present invention relates to an extract of East Asia scorpion which has the function of preventing and / or treating oral epithelial cancer and its medicine for preventing and / or treating oral epithelial cancer, as well as the preparation method and application of the extract of East Asia scorpion. The preparation method Including extracting an anti-oral epithelial cancer site from the venom-gland-removed East Asian scorpion, and proving the effect and safety of the extract through an effective method. Background technique [0002] Scorpion is a traditional Chinese medicine commonly used in traditional Chinese medicine. It mainly refers to the dried worm body of Buthus martensic Karch, which is used clinically in traditional Chinese medicine to treat convulsions, convulsions, rheumatic arthralgia and other diseases. With the development of biomedicine and biochemistry at home and abroad, the application fields of scorpion and scorpion toxin are const...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P35/00A61P1/02
Inventor 黄迎春左萍萍
Owner BIOCHEM ENG COLLEGE OF BEIJING UNION UNIV
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