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Andrographis root extraction and its preparing process and application

A technology of Andrographis paniculata root and extract, applied in the fields of Andrographis paniculata root extract and traditional Chinese medicine extract, which can solve the problems of discarding and waste

Inactive Publication Date: 2007-09-26
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing on the market are more traditional Chinese medicine preparations with Andrographis paniculata as main raw material, such as Chuandrographis tablets, Churographis capsules, Andrographolide dripping pills, Churographis injection, compound Churographis tablets, etc.; The raw materials and finished products mainly contain lactones, which are mainly used for heat-clearing and detoxifying, antibacterial and anti-inflammatory, and their quality control systems are mostly constructed with andrographolide; there are almost no preparations with andrographis flavonoids as the main drug, because flavonoids Substances mainly exist in the root of Andrographis paniculata, this part is not utilized in the preparation of Andrographis paniculata medicine, and it is often discarded, resulting in waste

Method used

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  • Andrographis root extraction and its preparing process and application
  • Andrographis root extraction and its preparing process and application
  • Andrographis root extraction and its preparing process and application

Examples

Experimental program
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Effect test

example 1

[0086] Get 2000g of dried Andrographis paniculata root, and grind it into coarse powder.

[0087] Take Andrographis paniculata root powder, add 40% ethanol 30 times, soak for 12 hours, heat and extract under normal pressure for 1.5 hours, filter while hot, add 20 times of 40% ethanol to the dregs, heat and extract for 1 hour, filter while hot, combine the two ethanol extract. Concentrate the ethanol extract under reduced pressure until it has no alcohol smell, centrifuge at 3000rpm at 5-20°C, take the supernatant and add it to the treated AB-8 macroporous adsorption resin (produced by Tianjin Nankai University Chemical Factory) to The flow rate of 2BV / h (column volume per hour) is applied to the macroporous adsorption resin column. After the adsorption is saturated, the resin column is first eluted with water at a flow rate of 1.5BV / h. , 60%, and 90% ethanol are eluted at a flow rate of 1BV / h, and the increase between the ethanol gradients is based on the colorless eluent fro...

example 2

[0091] Take 1000g of freshly dried Andrographis paniculata root, and grind it into coarse powder.

[0092] Take Andrographis paniculata root powder, add 50% ethanol 30 times, soak for 12 hours, heat and reflux under normal pressure for 1.0 hour, filter while hot, add 50% ethanol 20 times to the dregs, heat and reflux for 1 hour, filter while hot, Combine the two ethanol extracts. Concentrate the ethanol extract under reduced pressure until there is no alcohol smell, centrifuge at 2000rpm at 5-20°C, take the supernatant and add it to the treated AB-8 macroporous adsorption resin (produced by Tianjin Nankai University Chemical Factory) to The flow rate of 2BV / h (column volume per hour) is applied to the macroporous adsorption resin column. After the adsorption is saturated, the resin column is first eluted with water at a flow rate of 1.5BV / h. , 60%, and 90% ethanol are eluted at a flow rate of 1BV / h, and the increase between the ethanol gradients is based on the colorless elue...

example 3

[0094] Take 1000g of freshly dried Andrographis paniculata root, and grind it into coarse powder.

[0095] Take Andrographis paniculata root powder, add 20 times of 70% ethanol to soak for 12 hours, extract by heating and reflux under normal pressure for 1.5 hours, filter while hot, add 15 times of 50% ethanol to the dregs, extract by heating and reflux for 1 hour, filter while hot, Combine the two ethanol extracts. Concentrate the ethanol extract under reduced pressure until there is no alcohol smell, centrifuge at 2000rpm at 5-20°C, take the supernatant and add it to the treated AB-8 macroporous adsorption resin (produced by Tianjin Nankai University Chemical Factory) to The flow rate of 2BV / h (column volume per hour) is applied to the macroporous adsorption resin column. After the adsorption is saturated, the resin column is first eluted with water at a flow rate of 1BV / h. 60% and 90% ethanol were eluted at a flow rate of 1BV / h, and the increase between each ethanol gradie...

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Abstract

The invention provides a creat root extractive, characterized in that it comprises 53.28-68.53% chromocor with 6.85-11.38% 5, 2'-dihydroxy-7, 8-dimethyl ketone). And the preparation comprises that immerging creat root powder into alcohol, heating at normal pressure, refluxing and extracting, passing the alcohol extractive through large-hole adsorption resin, washing with alcohol, collecting the washed liquid whose alcohol density is 60-90%, depressurizing and concentrating, atomizing and drying, while the preparation holds the flavonoids as 7-O-methyl wogonin, creat chromocor, 5-hydroxy-7, 8, 2' 3'-tetrahydroxyflavone, 5-hydroxy-3, 7, 8, 2'-tetrahydroxyflavone, 5, 2'-dihydroxy-7, 8-dimethylketone, to hole the natural characters of creat root.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to extracts of traditional Chinese medicines, especially root extracts of andrographis paniculata. Background technique [0002] Andrographis paniculata (Burm.f.) Nees is a plant of the family Acanthaceae, and its root mainly contains flavonoids, andrographolide and other components. Modern pharmacological studies have shown that the flavonoids of Andrographis paniculata have cardiovascular pharmacological activity. Existing on the market are more traditional Chinese medicine preparations with Andrographis paniculata as main raw material, such as Chuandrographis tablets, Churographis capsules, Andrographolide dripping pills, Churographis injection, compound Churographis tablets, etc.; The raw materials and finished products mainly contain lactones, which are mainly used for heat-clearing and detoxifying, antibacterial and anti-inflammatory, and their quality control sys...

Claims

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Application Information

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IPC IPC(8): A61K36/19A61K31/352A61P7/02C07D311/30A61K125/00
Inventor 祝晨蔯林朝展
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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