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A kind of external pharmaceutical composition for treating male frequent urination, urgency and urinary incontinence, its preparation method and application

A technology for external use medicine and composition, applied to external use medicine composition for urinary incontinence, treatment of urinary frequency and urgency of urination, can solve the problems of unsatisfactory curative effect, low patient cognition, high recurrence rate, avoid liver first pass effect, enhanced therapeutic effect, less side effects

Active Publication Date: 2020-11-06
乐泰药业(兰西)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, despite the high incidence of OAB, patients' awareness of it is still low
[0006] Although there are many kinds of therapeutic drugs, the curative effect is not very satisfactory, it can only be suppressed but not eradicated, the recurrence rate is high, and western medicine treatment has certain side effects
In addition to drug therapy and health care product therapy, physical therapy and external massage therapy are indispensable, but there are still relatively few such products on the market

Method used

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  • A kind of external pharmaceutical composition for treating male frequent urination, urgency and urinary incontinence, its preparation method and application
  • A kind of external pharmaceutical composition for treating male frequent urination, urgency and urinary incontinence, its preparation method and application
  • A kind of external pharmaceutical composition for treating male frequent urination, urgency and urinary incontinence, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Preparation of an external pharmaceutical composition for treating male frequency, urgency, and urinary incontinence

[0044] Proceed as follows:

[0045] (1) Weigh an appropriate amount of ginger, pumpkin seed kernels, and saw palmetto fruit, freeze-dry them and pulverize them respectively. After passing through a 20-mesh sieve, the raw materials are respectively made of supercritical CO 2 Extraction extraction, the process flow chart is as follows figure 1 Shown:

[0046] 1) Preparation of ginger root oil: using supercritical CO 2 Extraction extraction, extraction pressure 25MP, temperature 35°C, CO 2 The flow rate is 35kg / h, the extraction time is 110min, and the ginger root oil is obtained for subsequent use;

[0047] 2) Pumpkin seed oil: using supercritical CO 2 Extraction extraction, extraction pressure 30MPa, temperature 40°C, CO 2 The flow rate is 20kg / h, the extraction time is 90min, and pumpkin seed oil is obtained for use;

[0048] 3) Saw pal...

Embodiment 2

[0051] Example 2 Preparation of an external pharmaceutical composition for treating male frequency, urgency, and urinary incontinence

[0052] Proceed as follows:

[0053] (1) Weigh an appropriate amount of ginger, pumpkin seed kernels, and saw palmetto fruit, freeze-dry them and pulverize them respectively. After passing through a 20-mesh sieve, the raw materials are respectively made of supercritical CO 2 Extraction extraction, the process flow chart is as follows figure 1 Shown:

[0054] 1) Preparation of ginger root oil: using supercritical CO 2 Extraction extraction, extraction pressure 30MP, temperature 30°C, CO 2 The flow rate is 30kg / h, the extraction time is 100min, and ginger root oil is obtained for subsequent use;

[0055] 2) Pumpkin seed oil: using supercritical CO 2 Extraction extraction, extraction pressure 35MPa, temperature 35°C, CO 2 The flow rate is 25kg / h, the extraction time is 120min, and the pumpkin seed oil is obtained for use;

[0056] 3) Saw pa...

Embodiment 3

[0059] Example 3 Preparation of an external pharmaceutical composition for treating male frequency, urgency, and urinary incontinence

[0060] Proceed as follows:

[0061] (1) Weigh an appropriate amount of ginger, pumpkin seed kernels, and saw palmetto fruit, freeze-dry them and pulverize them respectively. After passing through a 20-mesh sieve, the raw materials are respectively made of supercritical CO 2 Extraction extraction, the process flow chart is as follows figure 1 Shown:

[0062] 1) Preparation of ginger root oil: using supercritical CO 2 Extraction extraction, extraction pressure 35MP, temperature 40°C, CO 2 The flow rate is 20kg / h, the extraction time is 80min, and the ginger root oil is obtained for subsequent use;

[0063] 2) Pumpkin seed oil: using supercritical CO 2 Extraction extraction, extraction pressure 25MPa, temperature 30°C, CO 2 The flow rate is 35kg / h, the extraction time is 100min, and the pumpkin seed oil is obtained for use;

[0064] 3) Saw...

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Abstract

The invention discloses an externally applied pharmaceutical composition for treating urinary frequency, urinary urgency and urinary incontinence, and a preparation method and application thereof. Based on treatment according to syndrome differentiation, according to the difference of etiology and pathogenesis of urinary frequency, urinary urgency and urinary incontinence between men and women, aiming at improving urinary frequency, urinary urgency and urinary incontinence, and according to a theoretical study on the modern pharmacological effect and a study on the actual efficacy of the raw materials, active components with effects of improving urinary frequency, urinary urgency and urinary incontinence are extracted from traditional Chinese medicinal raw materials by applying a supercritical CO2 extraction method, the active components comprise ginger root oil, pumpkin seed oil, saw palmetto berry oil, borage seed oil and angelica oil, and the externally applied pharmaceutical composition for treating urinary frequency, urinary urgency and urinary incontinence of men or women is respectively obtained through scientific compatibility. Proven by experiments, when applied to the back of a patient and matched with massage for promoting drug absorption, the pharmaceutical composition has good curative effects of treating urinary frequency, urinary urgency and urinary incontinence, and has the advantages of natural raw materials, small side effect and the like.

Description

technical field [0001] The invention relates to an external pharmaceutical composition, in particular to an external pharmaceutical composition for treating urinary frequency, urgency and urinary incontinence, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Normal adults urinate 4 to 6 times during the day and 0 to 2 times at night, and the frequency increases significantly, which is called frequent urination. Frequent urination is a symptom rather than a disease. There are many reasons for frequent urination, including neuropsychiatric factors, physical weakness after illness, parasitic diseases, etc. Traditional Chinese medicine believes that frequent urination is mainly due to weak constitution, weak kidney qi, and bladder restraint. due to. In addition, due to excessive fatigue, the spleen and lungs are both deficient, the upper deficiency cannot control the lower, the soil deficiency cannot control water, and the bladde...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P7/12A61P13/00
CPCA61K9/0014A61K36/232A61K36/30A61K36/42A61K36/889A61K36/9068A61K2236/37A61K2300/00
Inventor 郎伟君
Owner 乐泰药业(兰西)有限公司
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