Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Total reflection near-field microscope combining with magnetic forceps for observing biomacromolecule

A technology of biological macromolecules and microscopes, applied in scanning probe microscopy, measuring devices, analyzing materials, etc., to achieve high measurement accuracy

Inactive Publication Date: 2007-09-26
INST OF PHYSICS - CHINESE ACAD OF SCI
View PDF1 Cites 23 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using this device can overcome the shortcoming that ordinary single near-field microscopes cannot flexibly control the force acting on single molecules, and can conveniently use magnetic beads to exert controllable forces on biological macromolecules, and real-time Rapid observation of biomacromolecules

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Total reflection near-field microscope combining with magnetic forceps for observing biomacromolecule
  • Total reflection near-field microscope combining with magnetic forceps for observing biomacromolecule
  • Total reflection near-field microscope combining with magnetic forceps for observing biomacromolecule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0029]The schematic diagram of the total reflection near-field microscope for observing biological macromolecules of the present invention is as shown in Figure 2: wherein the total reflection near-field microscope of the present invention includes a microscope imaging system 1, a micro sampler 2, a central processing system 3, and a magnetic tweezers sample Console 4 and sample reaction tank 5. The structural diagram of the magnetic tweezers sample console 4 is shown in Figure 3, which mainly includes the main sample stage 3-1, the slider 3-2, the magnetic tweezers 3-3, the slider control handle 3-4, and the slide shaft 3-5 , Middle groove 3-6. Wherein the magnetic tweezers 3-3 is fixed on the slider 3-2, and can move axially along the x-axis of the slider 3-5, the distance therebetween can be controlled by the slider control handle 3-4, the main sample stage 3 -1 is equipped with magnetic tweezers 3-3 and a magnetic tweezers control device, and the middle groove 3-6 is used...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

This invention relates to one whole reflection near field microscope to observe biology molecule, which comprises microscope lens imaging system, micro adding device, central process system, magnetic nipper control bench and sample reaction tank, wherein, the control bench comprises main sample bench, slide block, magnetic nipper, slide block control handle, slide axis and middle concave tank; the bench is fixed with magnetic nipper and control device and its middle concave tank is to fix sample reaction tank; the sample reaction tank is set on transparent closed system with both ends opened with sample supply; the inner biology large molecule one end is connected to upper surface and with other end connected with magnetic ball.

Description

technical field [0001] The invention belongs to single molecule manipulation and observation device. Specifically, the invention relates to a near-field microscope equipped with a magnetic tweezers device for observing biological macromolecules. Background technique [0002] For a relatively long period of time in the past, most of the studies on biological macromolecules, such as proteins and DNA, were carried out at the system level by using biochemical methods. In the past ten years, with the development of new technologies, many new research methods have emerged, such as: optical tweezers, magnetic tweezers, atomic force microscopy, etc., making it possible to study biological macromolecules from the single-molecule level. At the same time, with the development of microscope technology, using near-field microscope, a research tool with higher resolution, can observe the research object from a smaller scale. At present, these single-molecule studies have been increasing...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N13/14G01N21/00G01Q60/18
Inventor 孙志强翟永亮王鹏业窦硕星谢平王渭池
Owner INST OF PHYSICS - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com