Total reflection near-field microscope combining with magnetic forceps for observing biomacromolecule

A technology of biological macromolecules and microscopes, applied in scanning probe microscopy, measuring devices, analyzing materials, etc., to achieve high measurement accuracy

Inactive Publication Date: 2007-09-26
INST OF PHYSICS - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using this device can overcome the shortcoming that ordinary single near-field microscopes cannot flexibly control the force acting on single molecules, and can conveniently use magnetic beads to exert controllable forces on biological macromolecules, and real-time Rapid observation of biomacromolecules

Method used

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  • Total reflection near-field microscope combining with magnetic forceps for observing biomacromolecule
  • Total reflection near-field microscope combining with magnetic forceps for observing biomacromolecule
  • Total reflection near-field microscope combining with magnetic forceps for observing biomacromolecule

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Embodiment Construction

[0029]The schematic diagram of the total reflection near-field microscope for observing biological macromolecules of the present invention is as shown in Figure 2: wherein the total reflection near-field microscope of the present invention includes a microscope imaging system 1, a micro sampler 2, a central processing system 3, and a magnetic tweezers sample Console 4 and sample reaction tank 5. The structural diagram of the magnetic tweezers sample console 4 is shown in Figure 3, which mainly includes the main sample stage 3-1, the slider 3-2, the magnetic tweezers 3-3, the slider control handle 3-4, and the slide shaft 3-5 , Middle groove 3-6. Wherein the magnetic tweezers 3-3 is fixed on the slider 3-2, and can move axially along the x-axis of the slider 3-5, the distance therebetween can be controlled by the slider control handle 3-4, the main sample stage 3 -1 is equipped with magnetic tweezers 3-3 and a magnetic tweezers control device, and the middle groove 3-6 is used...

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Abstract

This invention relates to one whole reflection near field microscope to observe biology molecule, which comprises microscope lens imaging system, micro adding device, central process system, magnetic nipper control bench and sample reaction tank, wherein, the control bench comprises main sample bench, slide block, magnetic nipper, slide block control handle, slide axis and middle concave tank; the bench is fixed with magnetic nipper and control device and its middle concave tank is to fix sample reaction tank; the sample reaction tank is set on transparent closed system with both ends opened with sample supply; the inner biology large molecule one end is connected to upper surface and with other end connected with magnetic ball.

Description

technical field [0001] The invention belongs to single molecule manipulation and observation device. Specifically, the invention relates to a near-field microscope equipped with a magnetic tweezers device for observing biological macromolecules. Background technique [0002] For a relatively long period of time in the past, most of the studies on biological macromolecules, such as proteins and DNA, were carried out at the system level by using biochemical methods. In the past ten years, with the development of new technologies, many new research methods have emerged, such as: optical tweezers, magnetic tweezers, atomic force microscopy, etc., making it possible to study biological macromolecules from the single-molecule level. At the same time, with the development of microscope technology, using near-field microscope, a research tool with higher resolution, can observe the research object from a smaller scale. At present, these single-molecule studies have been increasing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N13/14G01N21/00G01Q60/18
Inventor 孙志强翟永亮王鹏业窦硕星谢平王渭池
Owner INST OF PHYSICS - CHINESE ACAD OF SCI
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