Gymnadenia conopsea extraction and its application in preparing medicine for treating pulmonary fibrosis

A technology of pulmonary fibrosis and palm ginseng, which is applied in the field of traditional Chinese medicine extracts and preparation of drugs for the treatment of pulmonary fibrosis, can solve the problems of large side effects and poor curative effect

Inactive Publication Date: 2010-05-12
LOGISTICS UNIV OF CAPF
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drugs used clinically for the treatment of pulmonary fibrosis have disadvantages such as large side effects and poor curative effect. It is very urgent and important to develop new drugs for the treatment of pulmonary fibrosis.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gymnadenia conopsea extraction and its application in preparing medicine for treating pulmonary fibrosis
  • Gymnadenia conopsea extraction and its application in preparing medicine for treating pulmonary fibrosis
  • Gymnadenia conopsea extraction and its application in preparing medicine for treating pulmonary fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A kind of ginseng extract, made by following method:

[0017] Ginseng palm crude drug is pulverized and sieved, soaked in 60% ethanol aqueous solution with volume percentage concentration 8 times of the weight of said palm ginseng crude drug powder for 24 hours, heated and refluxed for 2 hours, filtered, extracted 2 times, combined filtrate, and filtrate reduced The relative density is 1.05 when concentrated under pressure to 50 DEG C, promptly makes a kind of palm ginseng extract.

Embodiment 2

[0019] A kind of ginseng extract, made by following method:

[0020] Ginseng palm crude drug is pulverized and sieved, soaked in 70% ethanol aqueous solution with a volume percentage concentration 4 times the weight of the palm ginseng crude drug powder for 18 hours, heated and refluxed for 3 hours, filtered, extracted once, combined filtrate, and filtrate reduced The relative density is 1.2 when concentrated under pressure to 50 DEG C, promptly makes a kind of palm ginseng extract.

Embodiment 3

[0022] A kind of ginseng extract, made by following method:

[0023] Ginseng palm crude drug is pulverized and sieved, soaked in 50% ethanol aqueous solution with volume percentage concentration 10 times of the weight of said palm ginseng crude drug powder for 30 hours, heated and refluxed for 0.5 hour, filtered, extracted 3 times, combined filtrate, filtrate reduced The relative density is 1.1 when concentrated under pressure to 50 ℃, promptly makes a kind of palm ginseng extract.

[0024] Various pulmonary interstitial diseases (such as silicosis) and pulmonary fibrosis caused by collagen diseases have a similar pathological process: starting from alveolitis, leading to pulmonary fibrosis in the process of development and excessive repair. The present invention adopts rat tracheal exposure method to inject silica dust (50mg / only) to cause silicosis animal model, rats are divided into four groups at random, i.e. control group, silica dust group, palm ginseng treatment group, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention discloses one kind of conic gymnadenia tuber extract and its application in preparing medicine for treating pulmonary fibrosis. The conic gymnadenia tuber extract is prepared through crushing conic gymnadenia tuber, sieving to obtain conic gymnadenia tuber powder, soaking the conic gymnadenia tuber powder in 50-70 % concentration alcohol water solution of 4-10 time volume for18-30 hr, heating reflux to extract for 0.5-3 hr, filtering, repeating the extraction step for 1-3 times, merging the filtrate, decompression concentrating to density at 50 deg.c of 1.05-1.2. Experiment proves the treating effect of the conic gymnadenia tuber extract on pulmonary silicosis, and this reveals its use value in treating other pulmonary fibrosis diseases.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine extract and its application in preparing medicine for treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis is a disease characterized by diffuse alveolitis and alveolar structural disturbances that eventually lead to pulmonary interstitial fibrosis. Pulmonary fibrosis can be caused by various factors such as bacteria, dust, radioactive material, trauma, and drugs. Due to the high incidence rate and low cure rate of pulmonary fibrosis, it has become a disease that seriously endangers people's health due to the lack of effective therapeutic drugs. For example, pneumoconiosis, a disease that can cause pulmonary fibrosis, is a major occupational disease in my country. Since the 1950s, more than 580,000 pneumoconiosis cases have been reported in my country, more than 140,000 people have died, and more than 440...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61P11/00A61K125/00
Inventor 王世鑫汪骏曾锦波
Owner LOGISTICS UNIV OF CAPF
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap