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Use of bilobalide in the preparation of medicine for treating parkinsonism

A technology of Parkinson's disease and bilobalide, applied in the field of bilobalide in the preparation of drugs for the treatment of Parkinson's disease, can solve gene defects, have not prevented or cured Parkinson's disease, and cannot fundamentally protect the death of substantia nigra neurons, etc. question

Inactive Publication Date: 2008-01-02
苏州中药研究所有限公司
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Problems solved by technology

[0006] (3) Genetic defects: the current study found that 10 chromosomes are linked to Parkinson's disease in a Mendelian manner
The other three types are that although they can improve the motor symptoms of PD patients, they cannot fundamentally protect the substantia nigra neurons from death
It can be seen from the above that finding new drugs that can protect dopaminergic cells in the substantia nigra, and then combining existing drugs that can improve motor symptoms of PD can effectively treat PD and improve the quality of life and survival of PD patients. Drugs or treatments to prevent or cure Parkinson's disease

Method used

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  • Use of bilobalide in the preparation of medicine for treating parkinsonism
  • Use of bilobalide in the preparation of medicine for treating parkinsonism
  • Use of bilobalide in the preparation of medicine for treating parkinsonism

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Embodiment

[0034] Part 1 The therapeutic effect of bilobalide on experimental Parkinson's disease rats

[0035] With the aging of the population, the incidence of Parkinson's disease is gradually increasing. The current treatment methods are mainly drug therapy and surgical treatment. Among them, surgical treatment is expensive and risky, which limits its promotion. The drug treatment is now mainly dopamine replacement therapy, dopamine receptor agonists, etc., and there are few drugs that have a protective effect on the substantia nigra neurons. my country is a big country of natural medicines, and the resources of traditional Chinese medicine are very rich. Based on the important role of bilobalide in anti-ischemic injury, nerve excitation injury, and oxidative apoptosis, Parkinson's patients have oxidative stress in the substantia nigra and neuronal apoptosis. Death etc., considering the contrast between the two, so the present invention will explore the therapeutic effect of bilobalid...

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Abstract

The invention discloses the bilobalide application of preparing medicine that treats paralysis agitans. The bilobalide is effective for mouse paralysis agitans, and the mechanism is relevant with the activation of bilateral regulation NF-kb, reduced expression of apoptosis-promoting protein p53 and iNOS, and increased expression of apoptosis-resisting protein Bc1-2 and HSP60.According to this result, it can be proven that bilobalide can treat paralysis agitans at a certain degree.

Description

technical field [0001] The invention relates to the use of bilobalide in the preparation of medicaments for treating Parkinson's disease. Background technique [0002] In 1817, British doctor James Parkinson reported the first case of Parkinson's disease (PD), whose main clinical symptoms were tremor, rigidity, slow movement and abnormal posture and gait. Today, PD has become the second-ranked neurodegenerative disease (Neurodegenerative disease, ND) that endangers the health of middle-aged and elderly people. From a global perspective, the prevalence of Parkinson's disease in Western Europe and North America is about 70-180 / 100,000 people, and its annual incidence is 8-18 / 100,000 people. Among them, the prevalence rate of adults over the age of 40 is about 0.1%-0.2%, while that of the elderly over the age of 65 is even higher, with a prevalence rate as high as 1%. The latest domestic epidemiological survey results show that among the Chinese over the age of 55, the preval...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P25/16
Inventor 顾振纶秦正红赵喜林梁中琴殷梦龙陈仲良劳安娜周文轩郭次仪
Owner 苏州中药研究所有限公司
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