Development of paster for treating mouth ulcer

A technology of oral ulcers and patches, which is applied in compound pharmaceutical preparations in the field of medicine, can solve problems such as short maintenance time, unclear pathogenesis, and large dosage

Inactive Publication Date: 2008-01-02
朱靖华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the drugs commonly used for oral ulcers include anti-inflammatory drugs (metronidazole, tinidazole, etc.), corticosteroids (prednisone, dexamethasone, etc.), local analgesics (dyclonine, tetracaine, etc.) etc.) and drugs to promote ulcer healing (vitamin E, cod liver oil, etc.), but because the etiology of this disease is complicated and the pathogenesis is unclear, although there are many treatment methods, so far, there is no specific treatment drug
[0003] The traditional drug delivery carriers for the treatment of oral ulcers are mostly common oral preparations (such as metronidazole tablets), the disadvantages of which are mainly large dosage, long course of treatment, often accompanied by adverse reactions, lo

Method used

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  • Development of paster for treating mouth ulcer
  • Development of paster for treating mouth ulcer
  • Development of paster for treating mouth ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Prepare oral paste tablets made of Feilong Palm Blood and other medicinal materials, each weighing 200 mg, and the formula is as follows:

[0077] Flying Dragon Palm Blood 10mg Propolis 15mg

[0078] Dragon's Blood 20mg Borneol 2mg

[0079] Sodium lauryl sulfate 1mg polyethylene glycol 50mg

[0080] Dextrin 60mg Carbopol 40mg

[0081] Magnesium stearate 1mg

[0082] Acrylic resin 4.8mg Dioctyl phthalate 1.2mg

[0083] Dioxide peptide 1.2mg Yellow pigment 0.8mg

[0084] Preparation method: Take the medicine of Feilongzhang blood in the prescription, extract twice with 75% ethanol at reflux, 1 hour each time, combine the alcohol extract, concentrate under reduced pressure to dryness, add the prescription propolis, dragon blood, borneol and twelve Sodium alkyl sulfate is mixed uniformly, pulverized with a jet mill and passed through a 200-mesh sieve, and polyethylene glycol is added to 95% ethanol, milled uniformly, and spray-dried to obtain a solid dispersion. Take the above ...

Embodiment 2

[0087] Prepare oral paste tablets made of Feilong Palm Blood and other medicinal materials, each weighing 200 mg, and the formula is as follows:

[0088] Flying Dragon Palm Blood 15mg Propolis 17mg

[0089] Dragon's Blood 10mg Borneol 5mg

[0090] Sodium Carboxymethyl Cellulose 1mg Polyvinylpyrrolidone 50mg

[0091] Dextrin 60mg Carbopol 40mg

[0092] Micronized silica gel 2mg

[0093] Acrylic resin 4.8mg Dioctyl phthalate 1.2mg

[0094] Dioxide peptide 1.2mg Yellow pigment 0.8mg

[0095] Preparation method: Take the medicine of Feilong palm blood in the prescription, extract twice with 75% ethanol at reflux, 1 hour each time, combine the alcohol extracts, concentrate under reduced pressure to dryness, and add the propolis, dragon's blood, borneol and carboxymethyl in the prescription Sodium cellulose base and 1 / 2 amount of micro-powder silica gel are mixed uniformly, crushed with a jet mill and passed through a 200-mesh sieve, and polyethylene glycol is added to 95% ethanol, grin...

Embodiment 3

[0098] To prepare oral membranes made of Feilong Palm blood and other medicinal materials,

[0099] Flying Dragon Palm Blood 10mg Propolis 15mg

[0100] Dragon's Blood 20mg Borneol 2mg

[0101] Sodium lauryl sulfate 1mg carboxymethyl cellulose 100mg

[0102] Polyvinyl alcohol 50mg

[0103]Take the medicinal material of Feilong Palm blood in the prescription, reflux with 75% ethanol for 2 times, 1 hour each time, combine the alcohol extracts, concentrate under reduced pressure to dryness, and add the propolis, dragon blood, borneol and lauryl sulfate in the prescription Sodium is mixed uniformly, pulverized with a jet mill and passed through a 200-mesh sieve, and polyethylene glycol is added to 95% ethanol, ground uniformly, and spray-dried to obtain a solid dispersion. Take the above solid dispersion, add carboxymethyl cellulose and polyvinyl alcohol, add an appropriate amount of 75% ethanol, grind it evenly, and spread it with a spreader to make a mouth ulcer medicinal film.

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PUM

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Abstract

The invention discloses a plaster for treating ulcerative stomatitis, which is prepared from raw materials of Asiatic toddalia root, dragon's blood resin, bee glue liquid and baras camphor. The invention also relates to the process for preparing the plaster.

Description

Technical field [0001] The present invention relates to the application of a compound pharmaceutical preparation made of dragon's palm blood, dragon's blood, propolis and borneol in the field of medicine. Background technique [0002] Oral ulcer refers to the localized ulcer damage of the oral mucosa. It is the most common disease in oral mucosal disease. It has a high incidence and is easy to relapse. The common cold, dyspepsia, mental stress, and depression can all cause this disease. The disease usually occurs in areas with poor keratosis of the oral mucosa, and its etiology has not yet been fully confirmed. It is believed to be related to microbial infections, mental and neurological factors, digestive system diseases, endocrine dysfunction, genetics, vitamin and trace element deficiency, etc. In recent years, the commonly used drugs for oral ulcers include anti-inflammatory drugs (metronidazole, tinidazole, etc.), corticosteroids (prednisone, dexamethasone, etc.), and topica...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K9/70A61P1/02A61K35/64A61K31/045A61K35/644
Inventor 朱靖华
Owner 朱靖华
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