Hot plate experimentation on-line automatic detection device

Abstract

The present invention relates to an on-line detection equipment for heat plate test. Said invention includes a closed heat plate testing box, in its top portion an image sensor is mounted, and in its bottom portion a heat plate is set. A heating device, a temperature sensor and a pressure sensor are set in the heat plate interior and respectively connected with a heat plate control circuit. The image sensor is connected with computer by means of DSP image acquisition processing device and the heat plate control circuit is connected with said computer by means of a communication interface. Said invention can simultaneously use several groups of heat plate boxes to make test so as to raise detection efficiency.

Description

technical field [0001] The invention relates to a detection device, in particular to an online detection device for a hot plate test, in particular to a drug effect test for antipyretic and analgesic drugs in a pharmacological experiment. Background technique [0002] In pharmacological experiments, it is necessary to evaluate the efficacy of antipyretic and analgesic drugs, mainly to measure their influence on pain threshold, that is, thermal pain reaction time. The determination of pain threshold can be carried out by animal thermal pain response test, the most commonly used method is mouse hot plate test. The general method is to use a metal plate with good thermal conductivity, keep the temperature at 55°C±0.1°C, place the mouse on the metal plate, start the test immediately, and record the time as T s . At a room temperature of 15°C, generally mice begin to exhibit uncomfortable behaviors about 5 seconds after being stimulated by heat. The typical performance is to li...

AI Technical Summary

Problems solved by technology

The artificial timing hot plate test detection device is generally composed of a timer and a switch. During the experiment, the thermal pain response of the animal is manually observed and its incubation period is recorded. The board instrument needs to record the time through the panel buttons, foot switches or hand buttons, and cannot realize automatic timing

There are also some automatic recording devices that can record the time when animals feel pain and move their feet, such as the PLANTARTEST device of UGO BASILE biological research apparatus company, which can detect the 0.1-second return of animal limbs and claws through the built-in sensor of the infrared generator. However, the device only measures the time the animal continues to lift its foot, and it is difficult to effectively identify the posture of the animal licking the hind foot

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