Preparation method of surface reinforced Raman diffuse transmission substrate

A surface-enhanced Raman and substrate technology, applied in the fields of materials, biology, and optics, can solve the problems of limited nanoparticle size and inability to directly apply SERS

Inactive Publication Date: 2008-03-12
SHANGHAI INST OF OPTICS & FINE MECHANICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, the silver nanoparticles formed by this method are located inside the glass and require high-temperature annealing, and the size of the prepared nanoparticles is limited (the optimal size of the silver nanoparticles in the SERS substrate is about 100nm), which cannot be directly applied to SERS.

Method used

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  • Preparation method of surface reinforced Raman diffuse transmission substrate

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Experimental program
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Effect test

Embodiment 1

[0018] What the present embodiment selects is silver-doped silica glass (the content of silver ion is 0.1mol%), and the peak power of femtosecond laser is 2 * 10 11 W, focusing on the glass surface through a microscope objective lens, and scanning with a three-dimensional mobile platform to obtain a sensing area with a width of 50 microns and a length of 300 microns. The prepared glass is placed in silver nitrate solution, soaked for a certain period of time, grows into a noble metal film layer with nano-roughness, and forms a surface-enhanced Raman scattering substrate. Glycine with a concentration of 1 mol / L was dropped on the sensing area, and its Raman spectrum was measured to be 2500 times that of that without substrate, which realized the enhancement of the Raman spectrum of the sample, and the results are shown in Figure 1. In the figure (a) surface-enhanced Raman spectrum of glycine molecule, the measurement concentration is 1mol / L, and the integration time is 20 secon...

Embodiment 2

[0020] What this embodiment selects is silver-doped silica glass (the content of silver ion is 0.1mol%), utilizes pulse width to be 400 femtoseconds, repetition frequency 100 Hz, central wavelength 780 nanometers, power is 8 milliwatts (peak power is 2× 10 10 The laser light of W) is focused on the glass surface through a microscope objective lens, and scanned with a three-dimensional mobile platform to obtain a sensing area with a width of 50 microns and a length of 300 microns. The prepared glass is placed in silver nitrate solution, soaked for a certain period of time, grows into a noble metal film layer with nano-roughness, and forms a surface-enhanced Raman scattering substrate.

Embodiment 3

[0022] What this embodiment selects is silver-doped silica glass (the content of silver ion is 0.1mol%), utilizes pulse width to be 10 femtoseconds, repetition frequency 10 Hz, central wavelength 830 nanometers, power is 20 milliwatts (peak power is 2× 10 12 The laser light of W) is focused on the glass surface through a microscope objective lens, and scanned with a three-dimensional mobile platform to obtain a sensing area with a width of 50 microns and a length of 300 microns. The prepared glass is placed in gold chlorate solution, soaked for a certain period of time, and grows into a noble metal film layer with nano-roughness, forming a surface-enhanced Raman scattering substrate.

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Abstract

A method to produce surface enhanced Raman substrate (SERS) focalizes a laser beam with pulse width of 10 swung dash 500femtosecond, power of 1 swung dash 100milliwatt and peak power of 2 is multiplied by 109 swung dash 5 is multiplied by 1012W to form a light spot with a diameter of several microns, thus projecting the focalized light spot of the femtosecond laser beam onto a silicon glass surface mixed with precious metals, synchronously scanning the focalized light spot and forming a silicon glass substrate with nanometer roughness precious metal grains on its surface. And then the substrate is positioned to silver nitrate or aurum chlorate for steeping to form a precious metal film layer with nanometer roughness and obtaining a SERS. Relevant experiments indicate that the SERS produced according to the present invention is provided with a remarkably enhanced surface Raman scattering effect.

Description

technical field [0001] The invention relates to multiple fields such as optics, materials and biology, in particular a method for preparing a surface-enhanced Raman scattering substrate by using femtosecond laser micromachining technology. Background technique [0002] The development of life sciences has entered the era of detection and manipulation at the single-cell and single-molecule level. Because the optical method can be directly imaged, has the least interference to the research object, and has the advantages of non-destructive and in-situ measurement, it has become the preferred research method of life science. Raman spectroscopy can obtain the vibrational energy level information of molecules, which is called the "fingerprint spectrum" of molecules, and can provide detailed structural information of molecules, such as the type, strength, angle, and conformational changes of chemical bonds. However, the efficiency of ordinary Raman scattering is very low. In gener...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
Inventor 周增会程亚徐剑徐至展
Owner SHANGHAI INST OF OPTICS & FINE MECHANICS CHINESE ACAD OF SCI
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