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Nutritional supplement for HIV patients

A kind of use, oligosaccharide technology, applied in the field of preparation of nutritional supplements

Inactive Publication Date: 2008-04-16
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0029] However, although products are available that supply the general nutritional needs of HIV-infected patients, there are no nutritional products that both improve nutritional status and additionally significantly reduce or prevent specific HIV-infection-associated symptoms, especially Refers to the subject's immune dysfunction, bowel dysfunction and / or glutathione status

Method used

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  • Nutritional supplement for HIV patients
  • Nutritional supplement for HIV patients
  • Nutritional supplement for HIV patients

Examples

Experimental program
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preparation example Construction

[0136] Also provided is a preparation method of a composition for treating and / or preventing HIV, said method comprising:

[0137] -Provide an appropriate amount of one or more oligosaccharides;

[0138] -Provide an appropriate amount of cysteine ​​and / or a source of cysteine

[0139] - Formulation of the above two components into a suitable food or food supplement or pharmaceutical composition.

[0140] The following examples illustrate the invention. The practice of the present invention employs, unless otherwise indicated, standard conventional methods of molecular biology, pharmacology, immunology, virology, microbiology or biochemistry. These techniques are described in Sambrook and Russell (2001) Molecular Cloning: A Laboratory Manual, Third Edition, Cold Spring Harbor Laboratory Press, NY, Volumes 1 and 2 of Ausubel et al. (1994) Current Protocols in Molecular Biology, Current Protocols, USA and Remington 's Pharmaceutical Science, Mack Publishing Company, Philadelph...

Embodiment 1

[0142] Example 1. Blocking of DC-SIGN-Fc binding by acid oligosaccharides and GOS

[0143] Blocking DC-SIGN is known to prevent virus translocation from dendritic cells onto CD4 T cells. The inventors have surprisingly found that oligosaccharides are able to block DC-SIGN with varying potency. As shown in Table 1, acid oligosaccharides (AOS) pectin hydrolysates were the most effective. These results show that AOS prevents binding of the Fc fragment to DC-SIGN at minimal concentrations.

[0144] Table 1. Efficacy of DC-sign binding induced by oligosaccharides

[0145] Oligosaccharides

I.C.50(μg / ml)

Acid Oligosaccharides (Pectin Hydrolyzate)

200

Galacto-oligosaccharides (trans-galacto-oligosaccharides)

600

FOS (Inulin HP)

＞1000

[0146] Materials and Methods:

[0147] Serially diluted oligosaccharide preparations were plated on ELISA plates. Binding of DC-SIGN-Fc was determined by ELISA using anti-DC-SIGN-Fc...

Embodiment 2

[0148] Embodiment 2. A kind of nutritional bar composition

[0149] raw material

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Abstract

The present invention relates to a nutritional product for HIV patients. More specifically the invention relates to a nutritional composition that provides carefully selected nutritional ingredients including oligosaccharides and cysteine and / or a source of cysteine specifically supporting HIV patients with nutritionally related symptoms. This invention also relates to the manufacture of a nutritional supplement for use in HIV patients.

Description

technical field [0001] The present invention relates to a nutritional product for HIV patients. More specifically, the present invention relates to a nutritional composition that provides carefully selected nutritional ingredients specifically for HIV patients with nutritionally related symptoms. The invention also relates to the preparation of nutritional supplements for HIV patients. Background technique [0002] Infection with the human immunodeficiency virus (HIV) and the development of acquired immunodeficiency syndrome (AIDS) have had a major impact on national and global health, social, political, and economic outcomes. There are more than 40 million people infected with HIV-1 worldwide, most of whom live in Asia, sub-Saharan Africa and South America. Despite therapeutic advances over the past decade, including the development of highly active antiretroviral therapy (HAART), once an individual has become infected, viral eradication remains impossible. [0003] The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A61P31/18A61K31/70A23L33/00
CPCA23V2002/00A23L1/308A23L1/3053A23L1/3051A23L1/3008A23L1/296A61K31/70A23L1/3055A23L33/40A23L33/12A23L33/175A23L33/18A23L33/185A23L33/21A61P3/02A61P31/18A23V2250/54242A23V2250/5424A23V2250/1882A23V2250/0616A23V2250/28A23V2250/5062A23V2250/0634A23V2250/606A23V2250/6406
Inventor J·加森E·A·F·范托尔J·W·C·西杰本G·沃莱安
Owner NV NUTRICIA