Pseudo moving bed type chromatographic separating device

A technology of simulating moving bed and chromatographic separation, which is applied in the field of SMB devices, can solve the problem that the number of metering pumps cannot be reduced, and achieve the effect of precise control and effective reduction of usage

Inactive Publication Date: 2008-05-14
DAICEL CHEM IND LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, in the above system, since the opening / closing of the regulator utilizes the pulsation of the metering pump, the number of metering pumps to be used cannot be reduced

Method used

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  • Pseudo moving bed type chromatographic separating device
  • Pseudo moving bed type chromatographic separating device

Examples

Experimental program
Comparison scheme
Effect test

no. 1 example

[0099] As shown in FIG. 1 , the SMB apparatus of the present embodiment includes an annular flow path 2 formed by connecting four columns 1 a to 1 d in series, a first flow for supplying a mobile phase connected to the annular flow path 2 . 3, the second flow path 4 connected to the annular flow path 2 for supplying the sample, the third flow path 5 connected to the annular flow path 2 for discharging the mobile phase from the annular flow path 2 Three evaporators 7a to 7c connected in series with the fourth flow path 6 so that the mobile phase in the third flow path 5 is concentrated in the third flow path 5, for receiving the bottom liquid of the evaporator 7c storage tank 8, three evaporators 9a to 9c that are connected in series so that the mobile phase in the fourth flow path 6 is concentrated in the fourth flow path 6, and are used to receive the storage of the bottom effluent of the evaporator 9c A tank 10, a collection tank 11 connected to each top portion of the evapo...

no. 2 example

[0129] As shown in FIG. 3, in addition to the SMB device of the first embodiment, the SMB device of this embodiment further includes bypass pipes 5f and 6f and bypass flow rate control valves 5g and 6g.

[0130] The bypass pipe 5f is a pipe connecting the main pipe 5a between the regulator 5d and the flow rate control valve 5e to the main pipe 5a downstream of the flow rate control valve 5e, which is a bypass flow path in the present invention. The bypass flow rate control valve 5g is a valve that opens / closes the bypass pipe 5f, and the bypass flow rate control valve is a bypass flow rate regulator in the present invention. The bypass flow rate control valve 5g is designed, for example, as a valve whose opening degree can be adjusted more precisely than the flow rate control valve 5e. Examples of the combination of the flow rate control valve 5e and the bypass flow rate control valve 5g include a combination of a ball valve and a needle valve.

[0131] Further, the bypass pi...

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PUM

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Abstract

A pseudo moving bed type chromatographic separating device (SMB device), comprises four columns (1a) to (1d), an endless flow passage (2) formed of connecting flow passages (2a) to (2d) connecting the columns (1a) to (1d) in series, and third and fourth flow passages (5) and (6) for discharging a moving phase from any position of the endless flow passage (2). Regulators (5d) and (6d) and flow control valves (5e) and (6e) as flow regulators for opening and closing main pipes (5a) and (6a) on the downstream side of the regulators (5d) and (6d) are installed in the third and fourth flow passages (5) and (6). Thus, the discharge of the moving phase from the endless flow passage (2) can be controlled by a simple and highly durable structure.

Description

technical field [0001] The present invention relates to a simulated moving bed chromatography separation device capable of continuously taking out a mobile phase containing a target substance (the device is also referred to as "SMB device" hereinafter), and in particular, the present invention relates to a device capable of controlling The flow rate of the mobile phase being withdrawn from the SMB device. Background technique [0002] The SMB device is capable of continuously supplying a sample containing a target substance to a column, and is also capable of separating the target substance and continuously discharging a mobile phase containing the target substance. Therefore, SMB units are suitable for producing predetermined substances by fractional distillation. [0003] As such an SMB device, for example, FIG. 4 shows a known device including: an annular flow path 2 formed to have a function for separating a sample containing a target substance. A plurality of columns ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/46G01N30/32G01N30/44G01N30/88B01D15/00
CPCB01D15/3833B01D15/1842G01N30/02G01N30/32B01D15/1821
Inventor 蓑田稔治
Owner DAICEL CHEM IND LTD
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