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Detecting element for transferring characteristics of neuron signal between single neuron and multiple neuron cluster

A nerve signal, single neuron technology, applied in the field of research devices, can solve problems such as the limitation of the number of electrodes, and achieve the effect of reducing the number

Active Publication Date: 2010-06-09
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since each contact point of all these MEAs requires a lead-out line, the number of electrodes is limited by the array lead-out lines

Method used

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  • Detecting element for transferring characteristics of neuron signal between single neuron and multiple neuron cluster
  • Detecting element for transferring characteristics of neuron signal between single neuron and multiple neuron cluster
  • Detecting element for transferring characteristics of neuron signal between single neuron and multiple neuron cluster

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Embodiment Construction

[0016] like figure 1 As shown, a single neuron and multi-neuron cluster inter-neural signal transmission characteristics detection device, including the use of standard CMOS process design and realization of a large-scale micron-scale (with neuron dendrites and axon diameter) electrode array area and MOS switch network 10, nerve signal exciter array 8 and nerve signal detector array 9 integrated and realized by adopting standard CMOS process design. Among them, the micro-electrode array design adopts a structure similar to that of a computer MOS single-tube read-write memory, and the electrode array unit circuit is designed in the form of N rows and N columns. Each electrode unit circuit consists of two independent electrode points and two MOS switches. The two electrode points are respectively used as the excitation electrode point and the detection electrode point, and the two MOS switches control the working states of the excitation electrode and the detection electrode re...

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Abstract

The invention discloses a detection device of the transmission characteristics of nerve signals in single neurons and multi-neuron clusters, which is characterized in that the device includes an electrode unit which is distributed in array; the electrode unit includes: an excitation electrode and a detection electrode, and an excitation control switch and a detection control switch are respectively connected on the excitation electrode and the detection electrode. Compared with the prior art, the invention has the advantages that: the invention can greatly reduce the number of the external leading-out wires of the electrodes at the same time of leading the working state of each electrode point to be controllable, so the invention can overcome the disadvantage that the number of the leading-out wires is restricted along with the increase of the number of the electrode array. The invention can realize the micro-study of the transmission characteristics of the signals among single neuronsomas, dendrite, axon, etc. various structures and among neuron clusters.

Description

technical field [0001] The present invention relates to a research device for the transmission characteristics of neurons and neuron cluster electrical activity signals of vertebrates including humans, in particular to a single neuron and multi-neuron cluster inter-neural signal assisted by a microelectronic system Transfer characteristic detection device. Background technique [0002] In 1906, Italian scientist Camillo Golgi and Spanish scientist Santiago Ramóny Cajal discovered the structure of the nervous system. Over the past century, tens of thousands of scientists from various fields have devoted themselves to the research of neuroscience, opened up the path of modern neuroscience research, and laid the foundation of modern neuroscience. Since the 1940s, people have imitated the brain's logical thinking mode to build computers (computers) that have a huge impact on the development of human society, and at the same time formed a generalized neural network mathematical ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/04G01N33/48
Inventor 王志功吕晓迎潘海仙
Owner SOUTHEAST UNIV
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