A set of medicinal compositions for improving cognitive impairment and treating senile dementia

A technology for senile dementia and dysfunction, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of unstable quality, large dosage, unsatisfactory curative effect, etc.

Inactive Publication Date: 2008-06-04
张作光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine preparations adopt multi-target therapy in improving cognitive dysfunction and treating senile dementia. Its advantage is that it treats both symptoms and root causes, and has few side effects. Its mechanism of action is not clear, so its efficacy is also unsatisfactory

Method used

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  • A set of medicinal compositions for improving cognitive impairment and treating senile dementia
  • A set of medicinal compositions for improving cognitive impairment and treating senile dementia
  • A set of medicinal compositions for improving cognitive impairment and treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] See attached figure 1 10 kilograms of ginseng (conforming to the provisions of "The Pharmacopoeia of the People's Republic of China") are broken and decocted with 70% ethanol solution, separated and purified by chromatography, and dried at low temperature to obtain 0.4 kilograms of ginseng extract; According to the Pharmacopoeia of the People's Republic of China), it was broken and decocted with 75% ethanol solution, separated and purified by chromatography, and dried at low temperature to obtain 1.44 kg of Radix Paeoniae Alba extract; the extract obtained in the above steps was combined with 0.4 kg of Ginkgo biloba standard extract (EGB761) Mix and pulverize to obtain the medicinal extract composition of the present invention.

Embodiment 2

[0041] See attached figure 2 , directly add 4 grams of ginsenoside (R g1 +R e +R b1 ), 23 grams of paeoniflorin and 40 grams of Ginkgo biloba standard extract (EGB761) were mixed and pulverized together to obtain the pharmaceutical extract composition of the present invention.

Embodiment 3

[0043] Mix 1 kg of ginseng, 1.8 kg of white peony root and 0.04 kg of standard ginkgo leaf extract (EGB761) and ultrafinely pulverize to obtain the pharmaceutical composition of the present invention.

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Abstract

The invention discloses a drug combination used for improving cognitive function dysfunctions and treating senile dementia using ginseng, white paeony root and ginkgo leaves as raw materials. The invention also discloses the preparation method of the drug combination. The experiment confirms that the invention combination can significantly improve learning and memory ability of ageing rats dysmnesia caused by scopolamine, and meanwhile can increase acetylcholine content in the hippocampus of the subjective rats.

Description

technical field [0001] The invention relates to a group of pharmaceutical compositions for improving cognitive dysfunction and treating senile dementia made from extracts of ginseng, white peony root and ginkgo biloba, which can be used as medicine, nutrition and health food. [0002] The present invention also relates to a preparation method of the above-mentioned pharmaceutical composition for improving cognitive dysfunction and treating senile dementia. Background technique [0003] Cognitive impairment and dementia are common diseases of old age. As the average life expectancy of the world's population increases year by year, the global population tends to age, and the incidence of people with cognitive impairment and Alzheimer's disease is also rising sharply. According to epidemiological surveys, 20% to 25% of people in Europe and the United States The elderly suffer from cognitive impairment and senile dementia, and the death rate due to senile dementia has risen to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P25/28
Inventor 张作光
Owner 张作光
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