Fusion protein for seralbumin and interferon

A serum albumin and fusion protein technology, applied in the direction of albumin peptides, animal/human proteins, hybrid peptides, etc., can solve the problems of short plasma half-life, up to several months or even years, increasing patient suffering and treatment costs, etc. , to achieve the effect of prolonging the plasma half-life
CN101200503AInactive Publication Date: 2008-06-18INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE +2
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE
Publication Date
2008-06-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses a fusional protein of a serum albumin and an interferon, the coding of the fusional protein DNA sequence, as well as bacteria, barm, animal cell and plant cell of the DNA sequence. The fusional protein provided by the present invention includes a first district with at least 85 percents congeneric sequence of the artificial serum albumin and a second district with at least 85 percents congeneric sequence of the artificial interferon. Without changing the property of the fusional protein, the fusional protein can implement the replacement, deficit or addition of exceptional amide acid residue. A connecting peptide is arranged between the first district and the second district of the fusional protein provided by the present invention; the general formula of the connecting peptide is [GlyGly GlyGlySer]n and n is an integer from 1 to 10. The fusional protein provided by the present invention with the property of artificial interferon and prolonged half-value period will be widely applied in the medicine field.
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Description

[0001] This application is a divisional application of a Chinese patent application filed on August 10, 2001, with the application number 01124110.1 and the title of the invention "Fusion Protein of Serum Albumin and Interferon". technical field

[0002] The invention relates to a fusion protein, especially a fusion protein of serum albumin and interferon. Background technique

[0003] Serum albumin is an important component of plasma, and is also the carrier of many endogenous factors and exogenous drugs, and it is difficult to penetrate the glomerulus under normal circumstances. Human serum albumin (sequence 1) is a protein composed of 585 amino acid residues (A.Dugaiczyk et al., PNAS, 1982 79:71-75), its molecular weight is about 66.5KD, and its plasma half-life is as long as 2 weeks above.

[0004] Human serum albumin (HSA) is synthesized in cells in the form of a propeptide containing a signal peptide of 18 amino acid residues and 6 propeptides, which are excised durin...

Claims

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