Liver cancer related gene DLK1 and uses thereof

A liver cancer and gene technology, applied in the field of molecular biology and genetic engineering, can solve the problems of little knowledge and poor prognosis of liver cancer
CN101200719AInactive Publication Date: 2008-06-18CHINESE NAT HUMAN GENOME CENT AT SHANGHAI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHINESE NAT HUMAN GENOME CENT AT SHANGHAI
Publication Date
2008-06-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses an application of DLK1 gene for preparing a RNA interference medicine for remedying the primary liver cancer and provides a siRNA sequence which considers the DLK1 gene as a target point. The present invention comprises the carrier of the siRNA sequence which considers the DLK1 gene as the target point and a host cell and also provides a biological chip and a kit for remedying and diagnosing the liver cancer. The DLK1 is considered as the target point for preparing the medicine for remedying the primary liver cancer, which ensures that the liver cancer is likely to be conquered.
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Description

technical field

[0001] The present invention relates to the fields of molecular biology and genetic engineering, specifically, the present invention relates to liver cancer-related gene DLK1, a group of siRNAs targeting its mRNA sequence, and its use in the preparation of reagents for diagnosing liver cancer and drugs for gene therapy of liver cancer application. Background technique

[0002] At present, there are about 12 million patients with chronic hepatitis in my country, and about 300,000 people die of liver disease every year, 50% of which are primary liver cancer, accounting for about 45% of the death toll of liver cancer in the world. The vast majority are related to HBV and HCV infection. The incidence rate of liver cancer ranks 2-3 in my country, mainly in young and middle-aged men, and the incidence rate in East China is significantly higher than that in other regions. In recent years, it has continued to rise. In Shanghai, the incidence of liver cancer ranks t...

Claims

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