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Pharmaceutical composition containing memantine hydrochloride and huperzine A and preparation thereof

A technology of memantine hydrochloride and huperzine A, applied in the field of medicine, can solve the problem of low affinity

Inactive Publication Date: 2008-08-06
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there's no evidence that memantine prevents or delays neuropathy in Alzheimer's patients
The treatment of antagonistic glutamate can only slow down the deterioration of moderate and severe Alzheimer's disease. The affinity of memantine to GABA, dopamine, adrenaline, histamine and glycine receptors and voltage-dependent Ca2+, Na+ or K+ channels very low

Method used

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  • Pharmaceutical composition containing memantine hydrochloride and huperzine A and preparation thereof
  • Pharmaceutical composition containing memantine hydrochloride and huperzine A and preparation thereof
  • Pharmaceutical composition containing memantine hydrochloride and huperzine A and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 memantine hydrochloride and huperzine A tablet

[0020] prescription:

[0021]

[0022] Preparation:

[0023] Pass memantine hydrochloride and microcrystalline cellulose through an 80-mesh sieve respectively, and mix them uniformly by using the method of equal increments, and set aside; add huperzine A into pure water, stir fully to dissolve, and set aside; add the aqueous solution containing the drug to In the mixed powder, make soft materials, granulate with a 24-mesh sieve, dry, granulate with a 20-mesh sieve, add magnesium stearate and CMS-Na, mix well, and press a suitable die to form a tablet.

Embodiment 2

[0024] Embodiment 2: memantine hydrochloride and huperzine A capsules

[0025] prescription:

[0026]

[0027] Preparation:

[0028] Pass memantine hydrochloride and microcrystalline cellulose through an 80-mesh sieve respectively, and mix them uniformly by using the method of equal increase, and set aside; add huperzine A into 80% ethanol, fully stir to dissolve, and set aside; use the ethanol solution in which the drug is dissolved Add it to the mixed powder, make soft material, granulate with a 24-mesh sieve, dry, granulate with a 24-mesh sieve, add magnesium stearate, pack separately, and obtain.

Embodiment 3

[0029] Example 3: Memantine Hydrochloride and Huperzine A Chewable Tablets

[0030] prescription:

[0031]

[0032] Preparation:

[0033] Pass raw materials such as memantine hydrochloride through 80-mesh sieve respectively, and mix them uniformly by the method of equal increments, and set aside; add huperzine A to 2% PVP-k30 ethanol solution, fully stir to dissolve, and set aside; Add the mixture solution into the mixed powder, make soft material, granulate with a 16-mesh sieve, dry, granulate with a 20-mesh sieve, add other flavoring agents, sweeteners, and glidants, mix evenly, and compress into tablets.

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PUM

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Abstract

The invention relates to a medicinal composition containing memantine hydrochloride and huperzine A and a preparation method and purposes thereof. Memantine hydrochloride and huperzine A are used as active components to prepare the medicinal composition by mixing with an excipient acceptable in pharmacy. Using memantine hydrochloride and huperzine A as raw materials and mixing with a plurality of excipients with a specific category and proportion, the medicinal composition of the invention is developed into various oral preparations like tablets, capsules, dispersible tablets, chewable tablets, orally disintegrating tablets, buccal tablets, dropping pills and so on according to a technical means disclosed in the invention. The medicinal composition of the invention can be used for treating moderate or severe Alzheimer type dementia.

Description

technical field [0001] The invention relates to a pharmaceutical composition with memantine hydrochloride and huperzine A as active ingredients, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Alzheimer's disease (AD) mostly occurs in the elderly over 65 years old, and can cause the loss of memory, judgment, abstract thinking, reasoning ability, cognitive function, emotion, personality and spatial relationship in patients. In the end, they cannot take care of themselves, which brings a heavy burden to the patient's family and society. At present, there are about 6 million Alzheimer's patients in my country, accounting for one-third of the total number of patients in the world. There are about 1.8 million new cases and 1.05 million deaths every year. The incidence situation is very serious. With the gradual entry of China's aging society, the discovery, diagnosis, and treatment of Alzheimer's disease...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61K9/20A61K9/48A61P25/28A61K31/13
Inventor 陈瑞晶
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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