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Method of synthesizing monoisopropanolamine

A technology of isopropanolamine and synthesis method, which is applied in chemical instruments and methods, preparation of organic compounds, preparation of aminohydroxy compounds, etc., can solve the problems that cannot be directly used for synthesizing medicine and pesticide intermediates, high isomer content problem, to achieve the effect of low production cost, high product quality and less equipment investment

Active Publication Date: 2011-05-04
NANJING BAOCHUN CHEMICAL INDUSTRY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved in the present invention is that the content of 1-amino-2-propanol isomers synthesized by the existing method is relatively high (more than 3%), and cannot be directly used for the synthesis of medicine and pesticide intermediates, providing a A kind of synthetic method of new 1-amino-2-propanol, isomers are directly controlled within 1% in the synthesis stage, so that product-isopropanolamine (1-amino-2-propanol) can Meet the high-end needs of synthetic medicine, pesticides, flavors, fragrances and other products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 4650kg liquid ammonia and 350kg deionized water are fully mixed to form ammonia water (water accounts for 7%) to be transported with a high-pressure metering pump, and then another high-pressure metering pump is used to transport 1322kg cyclopropane and ammonia water to fully mix, then enter the preheater, preheat Heat to 120°C, and then enter the reactor with temperature controlled at 130-132°C and pressure controlled at 12.9-13.0Mpa. After 2.5 hours of reaction, the reaction mixture product first enters the flash tower with pressure controlled at 1.0Mpa. Control at 155-158°C, recover excess ammonia at the top of the tower, flash the materials in the tower kettle, and enter the dehydration tower for dehydration. -120°C, the isopropanolamine mixture obtained in the dehydration tower tank enters an isopropanolamine rectification tower (hereinafter referred to as a different tower), the pressure is controlled at -0.097Mpa, the tower tank temperature is controlled at 154~15...

Embodiment 2

[0016] Fully mix 4300kg liquid ammonia and 280kg deionized water to form ammonia water (water accounts for 6.5%) and transport it with a high-pressure metering pump, and then use another high-pressure metering pump to deliver 1145kg cyclopropane and ammonia water after fully mixing, enter the preheater, preheat Heat to 122°C, then enter the reactor with temperature controlled at 134-137°C and pressure controlled at 13.5-13.6Mpa. After 2 hours of reaction, the reaction mixture product first enters the flash tower with pressure controlled at 1.2Mpa. Control the temperature at 156-158°C, recover excess ammonia, flash the materials in the tower kettle, and enter the dehydration tower for dehydration. ℃, the isopropanolamine mixture obtained in the dehydration tower tank enters a different tower, the pressure of the first different tower is controlled at -0.098Mpa, the temperature of the tower tank is controlled at 148-150 °C, and the temperature at the top of the tower is controlle...

Embodiment 3

[0018] Fully mix 4610kg liquid ammonia and 410kg deionized water to form ammonia water (water accounts for 8%) and transport it with a high-pressure metering pump, and then use another high-pressure metering pump to deliver 1426kg cyclopropane and ammonia water after fully mixing, enter the preheater, preheat Heat to 123°C, then enter the reactor with temperature controlled at 130°C and pressure at 12.9Mpa. After 1.8 hours of reaction, the reaction mixture product first enters the flash tower with pressure at 0.9Mpa and the temperature of the tower at 153 -155°C, recover excess ammonia, flash the material in the tower tank, enter the dehydration tower for dehydration, control the pressure at -0.085Mpa, control the temperature at the top of the tower at 46-47°C, control the temperature of the tower tank at 116-118°C, and control the temperature in the dehydration tower tank The obtained isopropanolamine mixture enters a different tower, the pressure of the first different tower ...

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Abstract

The invention relates to a synthesis method of isopropanolamine. The synthesis method comprises the following steps: (1) liquid ammonia and water are mixed to form ammonia water which is mixed with propylene oxide; mixed solution is preheated until the temperature reaches 120 to 125 DEG C, and the inputting molar ratio of the ammonia and the propylene oxide is controlled within 10 to 15; (2) the materiel after preheating is delivered into a reactor, the reaction temperature ranges from 128 to 138 DEG C, the pressure ranges from 12.6 to 13.8MPa, and the reaction time ranges from 1.5 to 3 hours; (3) the surplus unreacted ammonia is separated from the obtained mixture after the reaction by using a flash distillation column, the pressure in the flash distillation column ranges from 0.6 to 1.6MPa, and the temperature of a column kettle ranges from 140 to 160 DEG C; (4) the mixture which is separated through the flash distillation column is delivered into a leading tower for rectification dehydration, the pressure in the leading tower ranges from minus 0.080 to minus 0.085MPa, the temperature at the top of the leading tower is 45 to 55 DEG C, and the temperature at the bottom in a towerkettle ranges from 110 to 130 DEG C; (5) the mixture after dehydration is delivered into a rectification column for rectification, the pressure in the rectification column ranges from minus 0.095 to minus 0.099MPa, the temperature in the column kettle ranges from 135 to 160 DEG C, the temperature at the top of the rectification column ranges from 60 to 70 DEG C, isopropanolamine products are obtained at the top of the rectification column, and the mixture composed of diisopropanolamine and triisopropanolamine is obtained in the column kettle. The synthesis method has simple production procedure, little equipment investment, and high product quality.

Description

technical field [0001] The present invention relates to a kind of synthetic method of monoisopropanolamine. technical background [0002] One isopropanolamine is 1-amino-2-propanol (chemical formula: CH 3 CH(OH)CH 2 NH 2 ), also known as monoisopropanolamine. Monoisopropanolamine has a wide range of uses: it can be used in daily chemicals such as detergents, liquid detergents, and shampoos; it can be used in fabrics, wool spinning, and leather auxiliaries; it can be used in cleaning agents for metal electronic liquid crystals and semiconductors; It can be used in the synthesis of medicines, pesticides and flavors and fragrances intermediates. [0003] Most of the industrial production methods of isopropanolamine are now using ammonia water or liquid ammonia and propylene oxide as raw materials to synthesize isopropanolamine series mixtures, and then gradually separate monoisopropanolamine, diisopropanolamine, and triisopropanolamine. Three products of isopropanolamine. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C215/12C07C213/04
Inventor 张书杭建荣张小燕
Owner NANJING BAOCHUN CHEMICAL INDUSTRY CO LTD
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