Method for preparing adriamycin-dipeptide complexes and applications

Abstract

The invention discloses a preparation method of an adriamycin-dipeptide compound. Dipeptide or polypeptide containing proline residue is connected to amino of the adriamycin by the acylation through the technique of peptide modification; the toxicity of the adriamycin can be reduced and at the same time the pro-drug can release the adriamycin under the action of tumor interstitial cells so as to ensure that the adriamycin can enrich around tumor tissue to improve the selectivity of the adriamycin to the tumor tissue. The preparation method of the invention has the advantages of fast reaction rate, short term, relatively high productive rate and purity.

Description

Preparation method and application of a doxorubicin-dipeptide complex technical field The invention belongs to the technical field of biology and medicine, and specifically relates to a preparation method and application of a doxorubicin-dipeptide complex with anticancer activity. Background technique Due to its extensive anti-tumor effects, doxorubicin is often used as a first-line drug in the treatment of cancer in the clinical treatment of liver cancer, gastric cancer, breast cancer, lung cancer, ovarian cancer and various blood cancers. However, adverse reactions such as myelosuppression and cardiotoxicity of doxorubicin often destroy the patient's immune function, seriously affecting the therapeutic effect. Therefore, finding a modification method to reduce the toxicity of doxorubicin and improve the selectivity of doxorubicin to tumor tissue has become one of the focuses of current research. A core of prodrug technology is that the structure of many anti-tumor smal...

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Problems solved by technology

However, in the prior art, the preparation method of doxorubicin-dipeptide complex is generally time-consuming, the reaction rate is low, and the yield and purity of the product are relatively low.

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