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Ion chromatogram-alkali liquor inhibition ultraviolet detecting amines compounds

A technology of amine compounds and ion chromatography, which is applied in the field of ion chromatography-alkali suppression of ultraviolet detection of amine compounds, can solve problems such as retention, accuracy doubts, and baseline drift

Inactive Publication Date: 2008-10-01
ZHEJIANG SHUREN UNIV
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  • Abstract
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Problems solved by technology

[0002] At present, high-performance liquid chromatography and ion chromatography are usually equipped with ultraviolet detectors. For amine compounds with ultraviolet-visible absorption, ultraviolet detectors can be directly used for detection, but for those amine compounds that have no absorption or absorption in the ultraviolet-visible region Weaker organic compounds are mostly detected by pre-column derivatization or post-column derivatization by UV. However, the operation of this method is complicated, and its accuracy has been questioned. There are also electrochemical detection methods, but electrochemical detection is often stable. Poor performance, serious baseline drift, and unsatisfactory reproducibility results. At present, many methods are still in the stage of theoretical discussion.

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  • Ion chromatogram-alkali liquor inhibition ultraviolet detecting amines compounds
  • Ion chromatogram-alkali liquor inhibition ultraviolet detecting amines compounds

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Embodiment

[0009] Separation and detection of toluene diisocyanate

[0010] Specific steps are as follows:

[0011] 1. Toluene diisocyanate (TDA) standard solution preparation: pipette analytically pure 2,4-toluene diisocyanate (containing a small amount of 2,6-toluene diisocyanate), add 6mol L -1 HCl is placed in an ultrasonic wave for heating and ultrasonic hydrolysis to prepare a concentration of 1000mg.L -1 Standard stock solution, when used, dilute the standard stock solution into a standard use solution according to the sample content.

[0012] 2. Ultraviolet scanning: Prepare a certain concentration of TDA, adjust different pH values ​​for ultraviolet scanning, and determine the optimum pH of 10 and the optimum absorption wavelength of 212nm.

[0013] 3. Selection of eluent: test different eluent ratios, and finally determine as

[0014] 10%CH 3 CN+20mmol·L -1 Na 2 SO 4 +10mmoL·L -1 h 2 SO 4 , can successfully separate 2,4-TDA and 2,6-TDA.

[0015] 4...

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Abstract

The present invention provides a novel amine detection method. The method comprises the procedures of connecting a suppresser between the separating column and the ultraviolet detector, selecting an appropriate suppressor according to the different absorption peaks of the substance under different pH conditions, and regulating the pH of the suppressing solution to obtain that an optimum pH value of the strongest absorption peak is provided at ultraviolet-visible field. Thereby the sensitivity for measuring is greatly increased, and the method can be applied for the amine compound in the fields of environment monitoring, food safety, biomedicine, disease prevention and the like.

Description

technical field [0001] The present invention provides a new method for the determination of amines using ion chromatography-ultraviolet detection. During the measurement, the amine compounds are first acidified into amine cations by eluent, and then separated by cation exchange columns. The ultraviolet absorption of amine cations is relatively weak, and the sensitivity of ultraviolet detection is very low. Therefore, the separated sample solution first passes through a cation suppressor, and the inhibitory solution uses a strong alkali solution of potassium hydroxide to enhance the ultraviolet absorption of amine ions. Then enter the detector for detection. This method can be used for some amine compounds that have no absorption or weak absorption under acidic conditions and significantly enhanced absorption under alkaline conditions. Background technique [0002] At present, high-performance liquid chromatography and ion chromatography are usually equipped with ultraviolet ...

Claims

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Application Information

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IPC IPC(8): G01N30/74G01N30/02
Inventor 陈梅兰朱岩费栋
Owner ZHEJIANG SHUREN UNIV