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Self-emulsifying vitamin C preparation and method of preparing the same and application thereof

A vitamin and self-emulsifying technology, applied in cosmetic preparations, skin care preparations, cosmetics, etc., can solve the problems of unstable vitamin C and difficult absorption, and achieve the effect of stable product quality and good self-emulsifying performance

Inactive Publication Date: 2010-08-04
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the instability of vitamin C itself and the lack of easy absorption by the skin, the present invention provides a self-emulsifying vitamin C preparation, which can not only effectively increase the stability of vitamin C, but also self-emulsify in water to form The vitamin C emulsion brings convenience to the preparation of cosmetics containing vitamin C

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Weigh 10% egg yolk lecithin, 27% isopropyl myristate, 22% polyethylene glycol caprylic / capric glyceride, 30% glycerol, 1% vitamin E, respectively. The above mixture was dissolved at 60°C to form mixed solution A; then 10% vitamin C aqueous solution was added to solution A at 40°C and a stirring speed of 500 min-1 to form a transparent self-emulsifying vitamin C preparation. The vitamin C aqueous solution adopts citric acid and sodium citrate buffer at pH 5.5, and the concentration of vitamin C in the buffer is 15%.

Embodiment 2

[0044] Weigh 1% soybean lecithin, 15% sorbitan monooleate, 22% sorbitan monooleate, 25% natural squalane, 2% ubiquinone and 25% butanediol, heated in a water bath at 45°C to form mixed solution A; then add 10% vitamin C aqueous solution to solution A at 60°C and a stirring speed of 600min-1 to form a transparent self-emulsifying vitamin C preparation . The vitamin C aqueous solution adopts citric acid and sodium citrate buffer at pH 6.0, and the concentration of vitamin C in the buffer is 20%.

Embodiment 3

[0046] Weigh 8% egg yolk lecithin, 4% caprylic / capric triglyceride, 6% dioctyl carbonate, 20% polyglycerol isostearate, 25% propylene glycol, 5% Polyvinyl alcohol, 2% vitamin E acetate, dissolve the above mixture in a 30°C water bath to form mixed solution A; then add 30% vitamin C to solution A at 30°C and a stirring speed of 2000min-1 Aqueous solution to form a transparent self-emulsifying vitamin C preparation. The vitamin C aqueous solution adopts sodium bicarbonate and disodium bicarbonate buffer solution with pH 6.0, and the concentration of vitamin C in the buffer solution is 25%.

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PUM

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Abstract

The invention relates to a self-emulsified vitamin C preparation, a preparation method and application thereof, which pertains to the technical field of the latex and the latex preparation. The preparation consists of a lecithin in the weight percentage of 1 to 10%, a surfactant in the weight percentage of 20 to 50%, a cosurfactant in the weight percentage of 10 to 30%, a lipid material in the weight percentage of 10 to 30%, an antioxidant in the weight percentage of 0.1 to 2% and the vitamin C aqueous solution in the weight percentage of 10 to 30%. The materials are mixed evenly by stirring,so as to obtain the self-emulsified vitamin C preparation with a transparent or semitransparent appearance. The preparation can be self-emulsified in the water and form the latex with the grain diameter less than 300nm; the quality of the preparation is steady, thereby being applied to a cosmetic comprising the vitamin C.

Description

technical field [0001] The invention relates to a self-emulsifying preparation, in particular to a self-emulsifying vitamin C preparation, a preparation method and application thereof, and belongs to the technical field of cosmetics. Background technique [0002] Vitamin C plays an important role in biological redox and cellular respiration. Vitamin C is involved in amino acid metabolism, neurotransmission synthesis, collagen and tissue cell synthesis. In the dermatology clinic, high-dose oral vitamin C is used to treat acquired pigmentation disorders such as liver spots (brown spots) and Lille melanoderma, and it has obvious effects. Vitamin C can inhibit the deposition of abnormal pigment on the skin, inhibit the reaction of tyrosine-tyrosinase and play an anti-sensitizing effect. The production of melanin, thereby whitening the skin. [0003] Vitamin C is water-soluble and difficult to be absorbed by the skin, and the stability of vitamin C water is relatively poor, whi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/84A61K8/67A61Q19/00
Inventor 段明星谢静红周华锋郑昌学严泽民
Owner TSINGHUA UNIV
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