Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

New purpose of brevifolin

A technology of brevifolia hematoxylin and medicine, which is applied in the field of brevifolia hematoxylin in the field of medicine, and can solve the problem of rare pomegranate leaves

Inactive Publication Date: 2008-10-08
TSINGHUA UNIV
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The records of pomegranate leaves as a medicine for preventing and treating obesity are relatively rare, especially the use of brevifolia hematoxylin in the preparation of drugs for the transformation of pre-adipocytes into adipocytes and the accumulation of lipids in adipocytes (such as obesity) has not been reported. Applications

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New purpose of brevifolin
  • New purpose of brevifolin
  • New purpose of brevifolin

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0025] The following preparation method and drug effect experiment data make the preparation and application of the said brevicol of the present invention confirmed, and the following examples should not be regarded as limiting the present invention simultaneously.

[0026] The brevifolia hematoxylin of the present invention is obtained by the following method: firstly, reflux extracting 5-15 times the weight of the medicinal material with 60%-95% ethanol, the extraction frequency is generally 1-3 times, and each time is 1-3 hours. Concentrate the extract at normal pressure or reduced pressure at a temperature of 30-90°C to recover ethanol. Add methanol to dissolve, mix the sample with macroporous resin AB-8, pack it into a column, and then elute with 4-8 times column volume of water and 30-90% ethanol respectively, and collect the ethanol eluate part. Concentrate the collected eluate under reduced pressure at 30-80°C, extract with ethyl acetate, take the extracted part of eth...

Embodiment 1

[0028] Get 0.5 kg of pomegranate leaves and extract once with 80% ethanol reflux of 6 times its weight, each time for 1 hour. The extract was decompressed, concentrated at a temperature of 45°C, recovered ethanol, dried, and weighed. Add methanol to dissolve, stir into macroporous adsorption resin (AB-8) and pack into column, then use 4 times of column volume of water and 4 times of column volume of 90% ethanol to elute respectively, and collect the latter part of the eluate. The collected eluate was concentrated under reduced pressure at a temperature of 30° C., and dried under reduced pressure to obtain brevifolia hematoxylin. As determined by high performance liquid chromatography, the purity of the brevichematoxylin is about 80%.

Embodiment 2

[0030] Get 0.5 kg of hematoxylin and use 15 times of the weight of the material to extract 2 times with 80% ethanol under reflux, each time for 3 hours. Concentrate the extract to recover ethanol, add water, extract with ethyl acetate, take the extract, mix it with polyamide (60-80 mesh) and pack it into a column, elute with 6 times the column volume of ethanol-water (50:50), collect and elute liquid. The collected eluate was concentrated under reduced pressure at 60° C., and the precipitate was dried under normal pressure to obtain brevifolia hematoxylin. The brevifolia hematoxylin is determined by high performance liquid chromatography, and the brevifolia hematoxylin has a purity of about 90%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A new application of brevifolin relates to the new application in medicine of the brevifolin made from pomegranate leaf, in particular to medicinal application of the brevifolin for preventing preadipocyte in body from transforming to fat cell and treating disease caused by transformation. Experiments and studies show that the brevifolin has the effects of inhibiting intracellular TG from accumulating when the preadipocyte transforms to the fat cell, the activity of intracellular 3-phosphate dehydrogenase from increasing and in the late stage of differentiation and the activity of LPG from increasing in the accumulation of the intracellular TG in the fat cell. Therefore, the brevifolin can be used for preventing and treating obesity. When treating the obesity, the brevifolin is taken as active component. Furthermore, the brevifolin can be used independently or the brevifolin and other medicine are made into medicine with different forms for clinical use.

Description

technical field [0001] The invention relates to a new medical application of brevifolia hematoxylin extracted from pomegranate leaves, which belongs to the technical field of traditional Chinese medicines. Background technique [0002] The leaves of pomegranate are the leaves of Punica granatum L. in the pomegranate family. Pomegranate is a deciduous shrub or tree, usually 2-5 meters high, with blue-gray bark. The young branches are nearly round or slightly quadrangular, and the tops of the branches are usually spiny, glabrous. The leaves are opposite or clustered; the leaves are obovate to oblong, 2.5-6cm long and 1-1.8cm wide. Apex pointed or slightly concave, base attenuate, margin entire, upper surface shiny, glabrous, lower surface with a raised main vein, with a short stalk. Pomegranate is a common fruit tree, which is cultivated in both the north and the south of my country, and the planting area in Jiangsu, Henan and other places is relatively large. In terms of a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/352A61K36/185A61P3/04A61K127/00
Inventor 邢东明雷帆王伟杜力军苏慧张晓娜林晗
Owner TSINGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com