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Bone marrow regeneration regulatory protein BRRG-1, encoding gene thereof and uses thereof

A technology of bone marrow regeneration and coding, which is applied in the fields of biotechnology and medicine, can solve the problems of few reports, and the molecular mechanism of bone marrow regeneration, differentiation and migration is not deep enough.

Inactive Publication Date: 2008-10-22
再生医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the current understanding of the molecular mechanisms of bone marrow regeneration, differentiation and migration is not deep enough, and there are few reports on the genes that regulate bone marrow regeneration, differentiation and migration

Method used

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  • Bone marrow regeneration regulatory protein BRRG-1, encoding gene thereof and uses thereof
  • Bone marrow regeneration regulatory protein BRRG-1, encoding gene thereof and uses thereof
  • Bone marrow regeneration regulatory protein BRRG-1, encoding gene thereof and uses thereof

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Abstract

The invention discloses an isolated protein BRRG-1 which has the functions of suppressing the regeneration, the differentiation and / or the migration of bone marrows. The invention also discloses the polynucleotide of encoding the protein, the production method for the protein and the application of the protein.

Description

technical field The present invention belongs to the fields of biotechnology and medicine; specifically, the present invention relates to a new protein with the function of inhibiting bone marrow regeneration, differentiation and / or migration, and a gene encoding the protein, and the present invention also relates to the use and use of the protein Preparation. Background technique Bone marrow is the main organ of hematopoiesis and is rich in pluripotent stem cells. At present, bone marrow transplantation has become the only treatment for many diseases. In addition to curing leukemia, bone marrow transplantation can also treat some other blood diseases, such as aplastic anemia, thalassemia, abnormal myelocytosis, and hereditary red blood cell abnormalities. disease, abnormal plasma cells, etc., as well as malignant tumors of the gonorrhea system, hereditary immunodeficiency, and severe radiation sickness. In recent years, the number of patients receiving bone marrow transpl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/435C12N15/12C12P21/02A61K38/17C07K16/18
Inventor 毛文伟韩伟梁迁
Owner 再生医药有限公司