Astaxanthin self-emulsifying soft capsule preparation and preparation thereof

A technology of self-emulsifying soft capsules and astaxanthin, which can be used in anti-toxic agents, pharmaceutical formulations, drug delivery, etc., and can solve the problems of low bioavailability and easy oxidation of astaxanthin

Inactive Publication Date: 2008-11-12
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fat solubility of astaxanthin, its bioavailability is not high, and astaxanthin is easily oxidized

Method used

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  • Astaxanthin self-emulsifying soft capsule preparation and preparation thereof
  • Astaxanthin self-emulsifying soft capsule preparation and preparation thereof
  • Astaxanthin self-emulsifying soft capsule preparation and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The raw materials of astaxanthin self-emulsifying soft capsule preparation are as follows:

[0022] Astaxanthin 1g, olive oil 60g, Tween 8530g, ethanol 10g.

[0023] Weigh astaxanthin, oil, emulsifier and co-emulsifier according to the components, and add N 2 To prevent it from oxidizing, ultrasound at 40°C for 30 minutes, and shaking in water at 40°C for 1 hour, the astaxanthin self-emulsifying drug delivery system is obtained, which is cooled to room temperature and compressed into 200 soft capsules.

[0024] The prepared astaxanthin self-emulsifying soft capsule preparation and the oil solution of astaxanthin were subjected to a dissolution comparison test.

[0025] Dissolution test method:

[0026] In accordance with the second method of Appendix XC of the 2005 edition of the Chinese Pharmacopoeia, one astaxanthin self-emulsifying soft capsule is placed in sedimentation blue, and 900ml of water, artificial gastric juice, and artificial intestinal juice are used as disso...

Embodiment 2

[0036] The raw materials of astaxanthin self-emulsifying soft capsule preparation are as follows:

[0037] Astaxanthin 1g, peanut oil 20g, polyoxyethylene hydrogenated castor oil 60g, polyethylene glycol 40020g.

[0038] Weigh astaxanthin, oil, emulsifier and co-emulsifier according to the components, and add N 2 To prevent its oxidation, ultrasound at 30°C for 40 minutes and shaking at a constant temperature of 40°C for 2 hours to obtain an astaxanthin self-emulsifying drug delivery system, which is then cooled to room temperature and compressed into 200 soft capsules.

Embodiment 3

[0040] The raw materials of astaxanthin self-emulsifying soft capsule preparation are as follows:

[0041] Astaxanthin 1g, glyceryl oleate 30g, polyethylene glycol-8-glyceryl caprylic acid 50g, propylene glycol 20g.

[0042] Weigh astaxanthin, oil, emulsifier and co-emulsifier according to the components, and add N 2 To prevent its oxidation, ultrasound at 45°C for 30 minutes and shaking at a constant temperature of 45°C for 3 hours to obtain an astaxanthin self-emulsifying drug delivery system, which was cooled to room temperature and then compressed into 200 soft capsules.

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Abstract

The invention discloses an astaxanthin self-emulsifying soft capsule preparation and a method for preparing the same, which relates to an astaxanthin preparation, in particular to the astaxanthin self-emulsifying soft capsule preparation capable of self-emulsifying in a body after oral administration as well as the method for preparing the same. The invention provides the astaxanthin self-emulsifying soft capsule preparation which has high bioavailability and good oxidation resistance and can self-emulsify in the body after the oral administration. The compositions of the astaxanthin self-emulsifying soft capsule preparation and the content by mass ratio are as follows: astaxanthin raw material: oil phase: emulsifier: coemulsifier is equal to 1: 20-60: 10-70: 0-30, wherein, an oil phase adopts natural vegetable oil or fatty acid ester, the emulsifier adopts nonionic emulsifier, and the coemulsifier adopts chain alcohol or short chain alcohol. The astaxanthin raw material, the oil phase, the emulsifier and the coemulsifier are added into a container, N2 is aerated into the container, and astaxanthin self-emulsifier is obtained by ultrasonic vibration; and the astaxanthin self-emulsifier is cooled to be the room temperature and is pressed to obtain the astaxanthin self-emulsifying soft capsule preparation.

Description

Technical field [0001] The invention relates to an astaxanthin preparation, in particular to an astaxanthin self-emulsifying soft capsule preparation which can be spontaneously emulsified in the body after oral administration and a preparation method thereof. Background technique [0002] Astaxanthin (Astaxanthin) is a high-quality, efficient and safe coloring agent and natural antioxidant. It is a fat-soluble carotenoid, which is widely present in the biological world, especially shrimp, crab and fish in aquatic animals. (Grung M. et al. Algalcarotenoids. Secondary carotenoids ZH Paplanospores as a source of (3s, 3's)-astaxanthin esters [J]. J. App Phycol, 1992, 4(2): 165-171). As a natural astaxanthin is a super antioxidant, called "super vitamin E", astaxanthin also has a variety of biological functions such as strengthening immunity, anti-cancer, preventing skin aging, maintaining the health of eyes and central nervous system, etc. (Tanaka T, Morishita Y, Suzui M, et al. Chem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/66A61K31/122A61P39/06
Inventor 朱铉倪静胡新颖杨琼苏志伟
Owner XIAMEN UNIV
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