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Urinalysis reagent for screening malignant galactophore disease and application thereof

A malignant and disease-related technology, which is applied in biological testing, material inspection products, and analysis by making materials undergo chemical reactions, can solve problems such as poor stability, insufficient pertinence, and wide range, and achieve improved stability, good sensitivity, and The effect of improving specificity and stability

Active Publication Date: 2011-07-27
武汉市晨康科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But its main shortcomings are: poor stability, after 3 months of storage, the color effect is significantly lower than that of freshly prepared reagents
Secondly, since this kind of reagent is only a qualitative test, there are still many uncertainties when it is used for early clinical diagnosis. In addition, at present, this kind of reagent is mainly used for large-scale screening, with a wide range and insufficient pertinence

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 urine test reagent of the present invention

[0023] Weigh 160 g of HgSO 4 Dissolved in 1000 ml of 6N sulfuric acid solution, it is liquid A;

[0024] Weigh 300 grams of Hg 2 (NO 3 ) 2 .2H 2 O is dissolved in 500 milliliters of 12N nitric acid solution, which is liquid B;

[0025] Weigh 1 gram of α-nitroso-β-naphthol and dissolve it in 50 milliliters of 6N nitric acid solution to be liquid C;

[0026] Weigh 1 gram of 4-aminoantipyrine and dissolve it in 50 milliliters of 6N nitric acid solution to be liquid D;

[0027] Mix the above four liquids carefully according to the following volume ratios to obtain the screening reagent for malignant breast diseases that meets the requirements:

[0028] V A :V B :V C :V D =7.0:2.9:0.06:0.04 is equivalent to a weight ratio of: HgSO 4 , Hg2 (NO 3 ) 2 .6H 2 O and α-nitroso-β-naphthol, 4-aminoantipyrine=1:1.8:0.0012:0.0008.

Embodiment 2

[0029] Embodiment 2 Preparation of urine test reagent of the present invention

[0030] Preparation raw material liquid is identical with embodiment 1, mixing ratio is as follows:

[0031] V A :V B :V C :V D =7.8:2.1:0.04:0.06 is equivalent to a weight ratio of: HgSO 4 , Hg 2 (NO 3 ) 2 .6H 2 O and α-nitroso-β-naphthol, 4-aminoantipyrine = 1.2: 1.44: 0.0008: 0.0012

Embodiment 3

[0032] Embodiment 3 Preparation of urine test reagent of the present invention

[0033] The method for preparing the raw material liquid is the same as in Example 1, and the mixing ratio is as follows: the weight ratio is: HgSO 4 , Hg 2 (NO 3 ) 2 .6H 2 O and α-nitroso-β-naphthol, 4-aminoantipyrine=1:1.7:0.0008:0.001.

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Abstract

The invention mainly discloses a new urine detection reagent which is used for screening breast malignant diseases and comprises A solution which is obtained by dissolving HgSO4 in 6N of sulfuric acid solution; B solution which is obtained by dissolving Hg2(NO3)2.2H2O in 12N of nitric acid solution; C solution which is obtained by dissolving alpha-nitroso-beta-naphthol in 6N of nitric acid solution; and D solution which is obtained by dissolving 4-aminophenazone in 6N of nitric acid solution; the four solutions mixing according to the following volume ratio, wherein the weight ratio of the HgSO4, the Hg2(NO3)2.2H2O and the alpha-nitroso-beta-naphthol and the 4-aminophenazone is: HgSO4:Hg2(NO3)2.2H2O:4-aminophenazone:alpha-nitroso-beta-naphthol=1:1.7-2:0.001-0.002:0.0008-0.002. The reagent is applied to the screening of breast malignant tumors, which is rapid, convenient and cheap and is beneficial to the early detection and early treatment of female cancers.

Description

technical field [0001] The invention relates to a novel urine test reagent for breast cancer screening. Background technique [0002] Malignant breast diseases mainly refer to breast cancer and its precancerous lesions. The concept of precancerous lesions of breast cancer is not very clear so far. In the past, through clinical prospective research, it was found that the rate of breast cancer in patients with hyperplasia of mammary glands was higher than that of ordinary women, so hyperplasia of mammary glands was considered to be a precancerous lesion of breast cancer. However, in recent years, most scholars at home and abroad believe that simple hyperplasia of the mammary glands does not cause cancer, but mainly occurs on the basis of high ductal epithelial hyperplasia and atypical hyperplasia. Therefore, high epithelial hyperplasia and atypical hyperplasia are regarded as precancerous lesion. However, some people believe that those with benign breast disease and epithel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/78G01N33/574
CPCG01N33/52
Inventor 皮勇建黄惠史宗洁
Owner 武汉市晨康科技有限责任公司
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